Abstract
Enantioselective radical cyclization reactions were performed in the presence of chiral complexing agent 1. The title compounds 3 yielded, depending on the 3′-substitution (R = H, Me), the corresponding endo- (4) or exo-product (5). The highest enantioselectivities (99% and 94% ee) were achieved with 2.5 equiv of complexing agent. The cyclization product trans-4 was obtained in 55% ee in the presence of only 0.1 equiv of complexing agent.
Original language | English |
---|---|
Pages (from-to) | 3145-3147 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 14 |
DOIs | |
State | Published - 6 Jul 2006 |