Chemical probes for labeling of the bacterial glucosaminidase nagZ via the huisgen cycloaddition

Ronald Orth, Maximilian Pitscheider, Stephan A. Sieber

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Glycoside hydrolases represent a large class of enzymes that cleave carbohydrate motifs. Since some enzymes play crucial roles in bacterial resistance pathways, we here introduce the synthesis and application of small sugar-based probes to study the function of the glycoside hydrolase NagZ.

Original languageEnglish
Article numberC01710SS
Pages (from-to)2201-2206
Number of pages6
JournalSynthesis
Issue number13
DOIs
StatePublished - 2010

Keywords

  • Carbohydrates
  • cycloaddition
  • glycoside hydrolases

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