Characterization of Lyophilization of Frozen Bulky Solids

Petra Foerst; Sebastian Gruber; Michael Schulz; Nicole Vorhauer; Evangelos Tsotsas

doi:10.1002/ceat.201900500

Characterization of Lyophilization of Frozen Bulky Solids

Petra Foerst, Sebastian Gruber, Michael Schulz, Nicole Vorhauer, Evangelos Tsotsas

Associate Professorship of Food Process Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Two methods to study the primary freeze-drying behavior of bulky solids are presented, namely, lyomicroscopy and neutron imaging. The applicability of both methods to visualize the evolution of the sublimation front is tested for maltodextrin particles with different sizes and solid concentrations. Exemplary results for both methods are reported and the applicability of both methods to study freeze-drying behavior of bulk solids is described. To estimate the impact of particle size and bed height for the freeze-drying of bulky solids, a modified Biot number is introduced to estimate the optimum particle size for a given bed height and formulation. The applicability of the two methods with regard to the modified Biot numbers is discussed.

Original language	English
Pages (from-to)	789-796
Number of pages	8
Journal	Chemical Engineering and Technology
Volume	43
Issue number	5
DOIs	https://doi.org/10.1002/ceat.201900500
State	Published - 1 May 2020

Keywords

Biot number
Bulk solids
Limiting particle size
Lyomicroscopy
Neutron imaging

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10.1002/ceat.201900500

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title = "Characterization of Lyophilization of Frozen Bulky Solids",

abstract = "Two methods to study the primary freeze-drying behavior of bulky solids are presented, namely, lyomicroscopy and neutron imaging. The applicability of both methods to visualize the evolution of the sublimation front is tested for maltodextrin particles with different sizes and solid concentrations. Exemplary results for both methods are reported and the applicability of both methods to study freeze-drying behavior of bulk solids is described. To estimate the impact of particle size and bed height for the freeze-drying of bulky solids, a modified Biot number is introduced to estimate the optimum particle size for a given bed height and formulation. The applicability of the two methods with regard to the modified Biot numbers is discussed.",

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AU - Foerst, Petra

AU - Gruber, Sebastian

AU - Schulz, Michael

AU - Vorhauer, Nicole

AU - Tsotsas, Evangelos

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AB - Two methods to study the primary freeze-drying behavior of bulky solids are presented, namely, lyomicroscopy and neutron imaging. The applicability of both methods to visualize the evolution of the sublimation front is tested for maltodextrin particles with different sizes and solid concentrations. Exemplary results for both methods are reported and the applicability of both methods to study freeze-drying behavior of bulk solids is described. To estimate the impact of particle size and bed height for the freeze-drying of bulky solids, a modified Biot number is introduced to estimate the optimum particle size for a given bed height and formulation. The applicability of the two methods with regard to the modified Biot numbers is discussed.

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Characterization of Lyophilization of Frozen Bulky Solids

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Keywords

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