Characteristics of haloethylene-induced acetonemia in rats

J. G. Filser, H. M. Bolt

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9 Scopus citations

Abstract

A series of halogenated ethylenes (vinyl chloride, vinylidene fluoride, cis- and trans-1,2-dichloroethylene, perchloroethylene) induces increased acetone exhalation in rats. Exposures of differently pre-treated rats to vinylidene fluoride suggest that a metabolite of the haloethylene must be envolved in eliciting this formation of acetone. This conclusion is based on (a) dependence of acetone exhalation on the concentration of vinylidene fluoride, (b) effect of inducing agents, (c) effect of pyrazol, a metabolic inhibitor, (d) effect of cysteine, (e) effect of hypoxia and (f) the time course of acetone exhalation.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalArchives of Toxicology
Volume45
Issue number2
DOIs
StatePublished - Jul 1980
Externally publishedYes

Keywords

  • 1,2-Dichloroethylenes
  • Acetonemia
  • Haloethylenes
  • Perchloroethylene
  • Vinyl Chloride
  • Vinylidene Fluoride

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