TY - JOUR
T1 - Characterising HIV-Indicator conditions among two nationwide long-term cohorts of people living with HIV in Germany (1999–2023)
AU - the HIV-1 Seroconverter, ClinSurv-HIV study groups
AU - Krings, Amrei
AU - Kollan, Christian
AU - Schmidt, Daniel
AU - Gunsenheimer-Bartmeyer, Barbara
AU - Valbert, Frederik
AU - Neumann, Anja
AU - Wasem, Jürgen
AU - Behrens, Georg M.N.
AU - Bickel, Markus
AU - Boesecke, Christoph
AU - Esser, Stefan
AU - Dröge, Patrik
AU - Ruhnke, Thomas
AU - Koppe, Uwe
AU - Rößler, Steve
AU - Güler, Cengiz
AU - Grüner, Beate
AU - Härter, Georg
AU - Marquardt, Simone
AU - Roll, Clemens
AU - Schnaitmann, E.
AU - Trein, A.
AU - Fritzsche, Carlos
AU - Audebert, Franz
AU - Berning, Christiane
AU - Schübel, Niels
AU - Baumann, Robert
AU - Mück, Birgit
AU - Schneider, Jochen
AU - Spinner, Christoph D.
AU - Pauli, Ramona
AU - Traidl-Hoffmann, Claudia
AU - Todorova, Antoniya
AU - Pullen, Oliver
AU - Sonntag, Barbara
AU - Hellerer, Ulrike
AU - Bogner, Johannes
AU - Vogelmann, Roger
AU - Ebert, Matthias P.
AU - Galle, Peter R.
AU - Sprinzl, Martin
AU - Claus, Bernd
AU - Ruck, Ines
AU - Weidemann, Jeannine
AU - Grünewald, Thomas
AU - Arbter, Peter A.
AU - Nicksch, Lennart
AU - Hamacher, Laura
AU - Vehreschild, Jörg Janne
AU - Fätkenheuer, Gerd
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - Background/Objective: Information about occurrence and affected groups of symptoms/diagnoses indicative of an HIV infection (so-called HIV indicator conditions; HIV-ICs) is lacking. We analyse HIV-IC incidence, transmission risks and immune status among people living with HIV (PLWH) antiretroviral therapy (ART) naive. Methods: Diagnoses reported for ART-naive PLWH from two multicentre observational, prospective cohort studies between 1999–2023 were analysed. Incidence rates per 1,000 person-years (PYs) were calculated for the overall study period and time periods defined by ART treatment recommendations. For further description, CD4 counts around HIV-IC diagnosis (+ -30 days) and HIV-transmission routes were collected. Results: In total 15,940 diagnoses of 18,534 PLWH in Germany were included. Of those 81% were male (median age: 36 years) and 56% reported being men, who have sex with men as the likely HIV-transmission route. Incidence rates varied between the different HIV-ICs. Syphilis had the highest incidence rate (34 per 1,000 PYs; 95% confidence interval [CI] 29–40) for sexually transmitted infections (STIs), hepatitis B was highest for viral hepatitis diagnoses (18 per 1,000 PYs; 95% CI 17–20); according to CDC-classification herpes zoster for HIV-associated diagnoses (22 per 1,000; 95% CI 20–24) and candidiasis for AIDS-defining diagnoses (30 per 1,000 PYs; 95% CI 29–32). Most PLWH with HIV-ICs (hepatitis, HIV-associated diagnoses and AIDS-defining conditions) had CD4 cell counts < 350. Conclusion: This analysis characterizes HIV-ICs regarding the incidence, HIV-transmission route and patients’ immune status. The results underline the importance of HIV-IC-based screening to detect PLWH with already partially impaired immune status and in need of timely ART initiation.
AB - Background/Objective: Information about occurrence and affected groups of symptoms/diagnoses indicative of an HIV infection (so-called HIV indicator conditions; HIV-ICs) is lacking. We analyse HIV-IC incidence, transmission risks and immune status among people living with HIV (PLWH) antiretroviral therapy (ART) naive. Methods: Diagnoses reported for ART-naive PLWH from two multicentre observational, prospective cohort studies between 1999–2023 were analysed. Incidence rates per 1,000 person-years (PYs) were calculated for the overall study period and time periods defined by ART treatment recommendations. For further description, CD4 counts around HIV-IC diagnosis (+ -30 days) and HIV-transmission routes were collected. Results: In total 15,940 diagnoses of 18,534 PLWH in Germany were included. Of those 81% were male (median age: 36 years) and 56% reported being men, who have sex with men as the likely HIV-transmission route. Incidence rates varied between the different HIV-ICs. Syphilis had the highest incidence rate (34 per 1,000 PYs; 95% confidence interval [CI] 29–40) for sexually transmitted infections (STIs), hepatitis B was highest for viral hepatitis diagnoses (18 per 1,000 PYs; 95% CI 17–20); according to CDC-classification herpes zoster for HIV-associated diagnoses (22 per 1,000; 95% CI 20–24) and candidiasis for AIDS-defining diagnoses (30 per 1,000 PYs; 95% CI 29–32). Most PLWH with HIV-ICs (hepatitis, HIV-associated diagnoses and AIDS-defining conditions) had CD4 cell counts < 350. Conclusion: This analysis characterizes HIV-ICs regarding the incidence, HIV-transmission route and patients’ immune status. The results underline the importance of HIV-IC-based screening to detect PLWH with already partially impaired immune status and in need of timely ART initiation.
KW - AIDS
KW - Acquired immune deficiency syndrome
KW - Cohort studies
KW - Germany
KW - HIV
KW - Human immunodeficiency virus
KW - Indicator conditions
UR - http://www.scopus.com/inward/record.url?scp=85208053054&partnerID=8YFLogxK
U2 - 10.1007/s15010-024-02419-2
DO - 10.1007/s15010-024-02419-2
M3 - Article
AN - SCOPUS:85208053054
SN - 0300-8126
JO - Infection
JF - Infection
ER -