Chapter 6: Disentangling Intercompartment Exchange from Restricted Diffusion

Mathias Schillmaier, Athanasia Kaika, Franz Schilling

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

5 Scopus citations

Abstract

Non-invasive assessment of intercompartment water exchange may be of importance to characterize pathologies which are subject to changes in membrane permeability either caused by the malignancy or as an effect of intervention. Conventional diffusion MRI is not specific to water exchange since it cannot separate the effects of exchange and restricted diffusion. For this purpose, advanced diffusion strategies based on a double-diffusion encoding have been developed to disentangle them. In this work, diffusion-based magnetic resonance methods and applications for the measurement of intercompartment exchange are reviewed.

Original languageEnglish
Title of host publicationIn-cell NMR Spectroscopy
Subtitle of host publicationFrom Molecular Sciences to Cell Biology
EditorsDaniel Topgaard
PublisherRoyal Society of Chemistry
Pages154-185
Number of pages32
Edition24
DOIs
StatePublished - 2020

Publication series

NameNew Developments in NMR
Number24
Volume2020-January
ISSN (Print)2044-253X
ISSN (Electronic)2044-2548

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