Changes in angiotensin peptides in plasma and urine in patients with anaphylaxis

Angiotensins (ANG) I and II were measured in the plasma of patients with hymenoptera venom allergy and found to be significantly decreased as com-pared to controls. An inverse correlation between the plasma levels of ANG I and ANG II and the intensity of clinical symptoms of anaphylaxis was observ-ed. In a separate study, ANG I and ANG II were measured in urine from healthy volunteers and from patients with anaphylactic reactions to drugs, food, and additives. An increase in both peptides was observed in patients with anaphylactic reactions during oral provocation. These findings suggest a pos-sible involvement of ANG peptides in anaphylactic reactions.