Chain Elongation of Thiodipeptides with Proteases

Carlo Unverzagt; Armin Geyer; Horst Kessler

doi:10.1002/anie.199212291

Chain Elongation of Thiodipeptides with Proteases

Carlo Unverzagt, Armin Geyer, Horst Kessler

TUM Emeriti of Excellence

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The C‐terminal elongation of thiopeptides 1 is not possible by chemical activation—thiazolones 2 are the major products. Now with proteases as catalysts, 1 has been converted without racemization into oligopeptides 3 with thioamide groups in defined positions. All = allyl. (Figure Presented.)

Original language	English
Pages (from-to)	1229-1230
Number of pages	2
Journal	Angewandte Chemie International Edition in English
Volume	31
Issue number	9
DOIs	https://doi.org/10.1002/anie.199212291
State	Published - Sep 1992

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title = "Chain Elongation of Thiodipeptides with Proteases",

abstract = "The C‐terminal elongation of thiopeptides 1 is not possible by chemical activation—thiazolones 2 are the major products. Now with proteases as catalysts, 1 has been converted without racemization into oligopeptides 3 with thioamide groups in defined positions. All = allyl. (Figure Presented.)",

author = "Carlo Unverzagt and Armin Geyer and Horst Kessler",

year = "1992",

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AU - Kessler, Horst

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AB - The C‐terminal elongation of thiopeptides 1 is not possible by chemical activation—thiazolones 2 are the major products. Now with proteases as catalysts, 1 has been converted without racemization into oligopeptides 3 with thioamide groups in defined positions. All = allyl. (Figure Presented.)

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JO - Angewandte Chemie International Edition in English

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IS - 9

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Chain Elongation of Thiodipeptides with Proteases

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