cGAS Conducts Micronuclei DNA Surveillance

Carina C. de Oliveira Mann, Philip J. Kranzusch

Research output: Contribution to journalShort surveypeer-review

47 Scopus citations

Abstract

DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP–AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.

Original languageEnglish
Pages (from-to)697-698
Number of pages2
JournalTrends in Cell Biology
Volume27
Issue number10
DOIs
StatePublished - Oct 2017
Externally publishedYes

Keywords

  • DNA damage
  • STING
  • cGAS
  • innate immune signaling
  • micronuclei

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