Abstract
DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP–AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.
Original language | English |
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Pages (from-to) | 697-698 |
Number of pages | 2 |
Journal | Trends in Cell Biology |
Volume | 27 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2017 |
Externally published | Yes |
Keywords
- DNA damage
- STING
- cGAS
- innate immune signaling
- micronuclei