Cerebrospinal fluid biomarkers in multiple sclerosis

Hayrettin Tumani; Hans Peter Hartung; Bernhard Hemmer; Charlotte Teunissen; Florian Deisenhammer; Gavin Giovannoni; Uwe K. Zettl

doi:10.1016/j.nbd.2009.04.010

Cerebrospinal fluid biomarkers in multiple sclerosis

Hayrettin Tumani, Hans Peter Hartung, Bernhard Hemmer, Charlotte Teunissen, Florian Deisenhammer, Gavin Giovannoni, Uwe K. Zettl

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Abstract

In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers in bodily fluids related to underlying disease mechanisms, disease activity and progression, and therapeutic response. Besides MR imaging parameters cerebrospinal fluid (CSF) biomarkers provide important and specific information since changes in the CSF composition may reflect disease mechanisms inherent to MS. The different cellular and protein-analytical methods of the CSF and the recommended standard of the diagnostic CSF profile in MS are described. A brief update on possible CSF biomarkers that might reflect key pathological processes of MS such as inflammation, demyelination, neuroaxonal loss, gliosis and regeneration is provided.

Original language	English
Pages (from-to)	117-127
Number of pages	11
Journal	Neurobiology of Disease
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/j.nbd.2009.04.010
State	Published - Aug 2009

Keywords

Axonal damage
Biomarker
Blood-CSF barrier
Blood-brain barrier
Cerebrospinal fluid
Clinically isolated syndrome
Demyelination
Glial activation
Multiple sclerosis
Remyelination

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10.1016/j.nbd.2009.04.010

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title = "Cerebrospinal fluid biomarkers in multiple sclerosis",

abstract = "In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers in bodily fluids related to underlying disease mechanisms, disease activity and progression, and therapeutic response. Besides MR imaging parameters cerebrospinal fluid (CSF) biomarkers provide important and specific information since changes in the CSF composition may reflect disease mechanisms inherent to MS. The different cellular and protein-analytical methods of the CSF and the recommended standard of the diagnostic CSF profile in MS are described. A brief update on possible CSF biomarkers that might reflect key pathological processes of MS such as inflammation, demyelination, neuroaxonal loss, gliosis and regeneration is provided.",

keywords = "Axonal damage, Biomarker, Blood-CSF barrier, Blood-brain barrier, Cerebrospinal fluid, Clinically isolated syndrome, Demyelination, Glial activation, Multiple sclerosis, Remyelination",

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AU - Tumani, Hayrettin

AU - Hartung, Hans Peter

AU - Hemmer, Bernhard

AU - Teunissen, Charlotte

AU - Deisenhammer, Florian

AU - Giovannoni, Gavin

AU - Zettl, Uwe K.

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AB - In patients with multiple sclerosis (MS) intensive efforts are directed at identifying biomarkers in bodily fluids related to underlying disease mechanisms, disease activity and progression, and therapeutic response. Besides MR imaging parameters cerebrospinal fluid (CSF) biomarkers provide important and specific information since changes in the CSF composition may reflect disease mechanisms inherent to MS. The different cellular and protein-analytical methods of the CSF and the recommended standard of the diagnostic CSF profile in MS are described. A brief update on possible CSF biomarkers that might reflect key pathological processes of MS such as inflammation, demyelination, neuroaxonal loss, gliosis and regeneration is provided.

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KW - Biomarker

KW - Blood-CSF barrier

KW - Blood-brain barrier

KW - Cerebrospinal fluid

KW - Clinically isolated syndrome

KW - Demyelination

KW - Glial activation

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KW - Remyelination

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Cerebrospinal fluid biomarkers in multiple sclerosis

Abstract

Keywords

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