Cerebral iron oxide distribution: In vivo mapping with MR imaging1

Claus Zimmer; Ralph Weissleder; Daniel O'Connor; Lawrence LaPointe; Thomas J. Brady; W. Scott Enochs

Cerebral iron oxide distribution: In vivo mapping with MR imaging¹

Claus Zimmer, Ralph Weissleder, Daniel O'Connor, Lawrence LaPointe, Thomas J. Brady, W. Scott Enochs

Massachusetts General Hospital

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

PURPOSE: To map the distribution of an iron oxide label in the central nervous system with in vivo magnetic resonance (MR) imaging. MATERIALS AND METHODS: Unilateral osmotic disruption of the blood-brain barrier (BBB) in rats (n = 40) was followed by injection of monocrystalline iron oxide nanoparticles (MION) into the carotid artery. MR images (1.5 T) were obtained in and ex vivo, and results were correlated with histologic section-matched iron maps. RESULTS: A mean of 0.2% of the injected MION was found in the brain 24 hours after unilateral osmotic disruption of the BBB. The spatial distribution of iron oxide within the brain correlated with areas known to have high relative perfusion. Iron was found in cell bodies and dendrites of cortical neurons and astrocytes and in the interstitial space. The threshold in concentration for detection of MION in the brain was 62.2 ng Fe/mm². CONCLUSION: MR imaging is well suited to noninvasive in vivo mapping of the intracerebral iron oxide distribution.

Original language	English
Pages (from-to)	521-527
Number of pages	7
Journal	Radiology
Volume	196
Issue number	2
State	Published - Aug 1995
Externally published	Yes

Keywords

Brain, blood flow, 10.12172, 10.12174
Brain, MR, 10.121411
Brain, perfusion, 10.12172, 10.12174
Iron
Magnetic resonance (MR), contrast enhancement

Cite this

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title = "Cerebral iron oxide distribution: In vivo mapping with MR imaging1",

abstract = "PURPOSE: To map the distribution of an iron oxide label in the central nervous system with in vivo magnetic resonance (MR) imaging. MATERIALS AND METHODS: Unilateral osmotic disruption of the blood-brain barrier (BBB) in rats (n = 40) was followed by injection of monocrystalline iron oxide nanoparticles (MION) into the carotid artery. MR images (1.5 T) were obtained in and ex vivo, and results were correlated with histologic section-matched iron maps. RESULTS: A mean of 0.2% of the injected MION was found in the brain 24 hours after unilateral osmotic disruption of the BBB. The spatial distribution of iron oxide within the brain correlated with areas known to have high relative perfusion. Iron was found in cell bodies and dendrites of cortical neurons and astrocytes and in the interstitial space. The threshold in concentration for detection of MION in the brain was 62.2 ng Fe/mm2. CONCLUSION: MR imaging is well suited to noninvasive in vivo mapping of the intracerebral iron oxide distribution.",

keywords = "Brain, blood flow, 10.12172, 10.12174, Brain, MR, 10.121411, Brain, perfusion, 10.12172, 10.12174, Iron, Magnetic resonance (MR), contrast enhancement",

author = "Claus Zimmer and Ralph Weissleder and Daniel O'Connor and Lawrence LaPointe and Brady, {Thomas J.} and Enochs, {W. Scott}",

year = "1995",

month = aug,

language = "English",

volume = "196",

pages = "521--527",

journal = "Radiology",

issn = "0033-8419",

publisher = "Radiological Society of North America Inc.",

number = "2",

}

TY - JOUR

T1 - Cerebral iron oxide distribution

T2 - In vivo mapping with MR imaging1

AU - Zimmer, Claus

AU - Weissleder, Ralph

AU - O'Connor, Daniel

AU - LaPointe, Lawrence

AU - Brady, Thomas J.

AU - Enochs, W. Scott

PY - 1995/8

Y1 - 1995/8

N2 - PURPOSE: To map the distribution of an iron oxide label in the central nervous system with in vivo magnetic resonance (MR) imaging. MATERIALS AND METHODS: Unilateral osmotic disruption of the blood-brain barrier (BBB) in rats (n = 40) was followed by injection of monocrystalline iron oxide nanoparticles (MION) into the carotid artery. MR images (1.5 T) were obtained in and ex vivo, and results were correlated with histologic section-matched iron maps. RESULTS: A mean of 0.2% of the injected MION was found in the brain 24 hours after unilateral osmotic disruption of the BBB. The spatial distribution of iron oxide within the brain correlated with areas known to have high relative perfusion. Iron was found in cell bodies and dendrites of cortical neurons and astrocytes and in the interstitial space. The threshold in concentration for detection of MION in the brain was 62.2 ng Fe/mm2. CONCLUSION: MR imaging is well suited to noninvasive in vivo mapping of the intracerebral iron oxide distribution.

AB - PURPOSE: To map the distribution of an iron oxide label in the central nervous system with in vivo magnetic resonance (MR) imaging. MATERIALS AND METHODS: Unilateral osmotic disruption of the blood-brain barrier (BBB) in rats (n = 40) was followed by injection of monocrystalline iron oxide nanoparticles (MION) into the carotid artery. MR images (1.5 T) were obtained in and ex vivo, and results were correlated with histologic section-matched iron maps. RESULTS: A mean of 0.2% of the injected MION was found in the brain 24 hours after unilateral osmotic disruption of the BBB. The spatial distribution of iron oxide within the brain correlated with areas known to have high relative perfusion. Iron was found in cell bodies and dendrites of cortical neurons and astrocytes and in the interstitial space. The threshold in concentration for detection of MION in the brain was 62.2 ng Fe/mm2. CONCLUSION: MR imaging is well suited to noninvasive in vivo mapping of the intracerebral iron oxide distribution.

KW - Brain, blood flow, 10.12172, 10.12174

KW - Brain, MR, 10.121411

KW - Brain, perfusion, 10.12172, 10.12174

KW - Iron

KW - Magnetic resonance (MR), contrast enhancement

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M3 - Article

C2 - 7617871

AN - SCOPUS:0029118142

SN - 0033-8419

VL - 196

SP - 521

EP - 527

JO - Radiology

JF - Radiology

IS - 2

ER -

Cerebral iron oxide distribution: In vivo mapping with MR imaging¹

Abstract

Keywords

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