Central vasopressin is modulated by chronic blockade of the renin- angiotensin system in experimental left ventricular hypertrophy

Frank Muders; Dietmar Elsner; Heribert Schunkert; Günter A.J. Riegger; Miklos Palkovits

doi:10.1016/S0895-7061(98)00177-0

Central vasopressin is modulated by chronic blockade of the renin- angiotensin system in experimental left ventricular hypertrophy

Frank Muders, Dietmar Elsner, Heribert Schunkert, Günter A.J. Riegger, Miklos Palkovits

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT₁ receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT₁ antagonists.

Original language	English
Pages (from-to)	311-314
Number of pages	4
Journal	American Journal of Hypertension
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/S0895-7061(98)00177-0
State	Published - Mar 1999
Externally published	Yes

Keywords

Angiotensin II
Angiotensin-converting enzyme
Aortic banding
Brain nuclei
Vasopressin
Ventricular hypertrophy

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10.1016/S0895-7061(98)00177-0

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title = "Central vasopressin is modulated by chronic blockade of the renin- angiotensin system in experimental left ventricular hypertrophy",

abstract = "We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT1 antagonists.",

keywords = "Angiotensin II, Angiotensin-converting enzyme, Aortic banding, Brain nuclei, Vasopressin, Ventricular hypertrophy",

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AU - Muders, Frank

AU - Elsner, Dietmar

AU - Schunkert, Heribert

AU - Riegger, Günter A.J.

AU - Palkovits, Miklos

PY - 1999/3

Y1 - 1999/3

N2 - We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT1 antagonists.

AB - We studied the interaction of the central renin-angiotensin system (RAS) and vasopressin system in rats with left ventricular hypertrophy (LVH) due to aortic banding. In these animals plasma vasopressin is elevated and vasopressin content is increased in specific brain areas. Chronic blockade of the RAS by angiotensin-converting enzyme (ACE) inhibition (ramipril) and AT1 receptor antagonism (losartan) significantly attenuated circulating and central vasopressin in rats with LVH. Given the antidiuretic, vasoconstrictive, and growth-promoting effects, vasopressin may participate in the cardiovascular alterations in LVH. Blockade of the RAS strongly ameliorates central and peripheral vasopressin. Therefore, central modulatory effects on vasopressin might contribute to the therapeutic efficacy of ACE inhibitors and AT1 antagonists.

KW - Angiotensin II

KW - Angiotensin-converting enzyme

KW - Aortic banding

KW - Brain nuclei

KW - Vasopressin

KW - Ventricular hypertrophy

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ER -

Central vasopressin is modulated by chronic blockade of the renin- angiotensin system in experimental left ventricular hypertrophy

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Keywords

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