TY - JOUR
T1 - Central pain after pontine infarction is associated with changes in opioid receptor binding
T2 - A PET study with 11C-diprenorphine
AU - Willoch, Frode
AU - Tölle, Thomas Rudolf
AU - Wester, Hans Jürgen
AU - Munz, Frank
AU - Petzold, Axel
AU - Schwaiger, Markus
AU - Conrad, Bastian
AU - Bartenstein, Peter
PY - 1999
Y1 - 1999
N2 - Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that 11C- diprenorphine PET provides unique information for the understanding of central poststroke pain.
AB - Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that 11C- diprenorphine PET provides unique information for the understanding of central poststroke pain.
UR - http://www.scopus.com/inward/record.url?scp=0342646955&partnerID=8YFLogxK
M3 - Article
C2 - 10319982
AN - SCOPUS:0342646955
SN - 0195-6108
VL - 20
SP - 686
EP - 690
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
IS - 4
ER -