TY - JOUR
T1 - Cell-type-specific modulation of feedback inhibition by serotonin in the hippocampus
AU - Winterer, Jochen
AU - Vanessa Stempel, A.
AU - Dugladze, Tamar
AU - Földy, Csaba
AU - Maziashvili, Nino
AU - Zivkovic, Aleksandar R.
AU - Priller, Josef
AU - Soltesz, Ivan
AU - Gloveli, Tengis
AU - Schmitz, Dietmar
PY - 2011/6/8
Y1 - 2011/6/8
N2 - Midbrain raphe nuclei provide strong serotonergic projections tothe hippocampus, in which serotonin (5-HT) exerts differential effects mediatedby multiple 5-HT receptor subtypes. The functional relevance of this diversity of information processingis poorly understood. Here we show that serotonin via 5-HT1B heteroreceptors substantially reduces synaptic excitation of cholecystokinin-expressing in-terneurons in area CA1 of the rat hippocampus, in contrast to parvalbumin-expressing basket cells. The reduction is input specific, affecting only glutamatergic synaptic transmission originating from CA1 pyramidal cells. As a result, serotonin selectively decreases feedback inhibition via 5-HT1B receptor activation and subsequently increases the integration time window for spike generation in CA1 pyramidalcells.Ourdataimplyanimportantrolefor serotonergicmodulationofGABAergic actioninsubcorticalcontrolofhippocampal output.
AB - Midbrain raphe nuclei provide strong serotonergic projections tothe hippocampus, in which serotonin (5-HT) exerts differential effects mediatedby multiple 5-HT receptor subtypes. The functional relevance of this diversity of information processingis poorly understood. Here we show that serotonin via 5-HT1B heteroreceptors substantially reduces synaptic excitation of cholecystokinin-expressing in-terneurons in area CA1 of the rat hippocampus, in contrast to parvalbumin-expressing basket cells. The reduction is input specific, affecting only glutamatergic synaptic transmission originating from CA1 pyramidal cells. As a result, serotonin selectively decreases feedback inhibition via 5-HT1B receptor activation and subsequently increases the integration time window for spike generation in CA1 pyramidalcells.Ourdataimplyanimportantrolefor serotonergicmodulationofGABAergic actioninsubcorticalcontrolofhippocampal output.
UR - http://www.scopus.com/inward/record.url?scp=79958279288&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.6382-10.2011
DO - 10.1523/JNEUROSCI.6382-10.2011
M3 - Article
C2 - 21653851
AN - SCOPUS:79958279288
SN - 0270-6474
VL - 31
SP - 8464
EP - 8569
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 23
ER -