TY - GEN
T1 - Cell transport using piezoelectric micro diaphragm pumps
AU - Bußmann, Agnes
AU - Thalhofer, Thomas
AU - Daum, Leopold
AU - Richter, Martin
AU - Hayden, Oliver
N1 - Publisher Copyright:
© VDE VERLAG GMBH · Berlin · Offenbach
PY - 2021
Y1 - 2021
N2 - New developments enable far-reaching cell culture research. However, many set-ups require manual fluid handling or bulky pump systems. The use of piezoelectric micropumps can enable further miniaturization and cost-efficient disposables, provided that cells are not damaged during transport. This work is first to investigate the impact of micropumps with flap valves on transported mammalian cells. The 5x5 mm2 silicon pump with 20 µm stroke height impacts cells causing 35.9 % dead cells compared to 5 % in the control sample. The larger steel pump has less impact, especially with adapted, soft actuation. Further evaluation and the design of adapted pumps can potentially improve cell culture and in vitro cell test applications.
AB - New developments enable far-reaching cell culture research. However, many set-ups require manual fluid handling or bulky pump systems. The use of piezoelectric micropumps can enable further miniaturization and cost-efficient disposables, provided that cells are not damaged during transport. This work is first to investigate the impact of micropumps with flap valves on transported mammalian cells. The 5x5 mm2 silicon pump with 20 µm stroke height impacts cells causing 35.9 % dead cells compared to 5 % in the control sample. The larger steel pump has less impact, especially with adapted, soft actuation. Further evaluation and the design of adapted pumps can potentially improve cell culture and in vitro cell test applications.
UR - https://www.scopus.com/pages/publications/85125182441
M3 - Conference contribution
AN - SCOPUS:85125182441
T3 - MikroSystemTechnik Kongress 2021: Mikroelektronik, Mikrosystemtechnik und ihre Anwendungen - Innovative Produkte fur zukunftsfahige Markte, Proceedings
SP - 290
EP - 293
BT - MikroSystemTechnik Kongress 2021
PB - VDE VERLAG GMBH
T2 - MikroSystemTechnik Kongress 2021: Mikroelektronik, Mikrosystemtechnik und ihre Anwendungen - Innovative Produkte fur zukunftsfahige Markte - MikroSystemTechnik Congress 2021: Microelectronics, Microsystems Engineering and their Applications - Innovative Products for Future-Oriented Markets
Y2 - 8 November 2021 through 10 November 2021
ER -