Abstract
Celiac disease, with a prevalence of about 1% in many countries, is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten (storage proteins of wheat, rye, barley, and oats) in genetically susceptible individuals. Small-intestinal villous atrophy is the characteristic feature, and symptoms include diarrhea or steatorrhea and extraintestinal manifestations. A strict, lifelong gluten-free diet is the current essential therapy. The complex pathomechanism consists of incomplete gluten digestion, para- and transcellular passage of gluten peptides through the epithelium, and adaptive and innate immune responses in the lamina propria.
Original language | English |
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Title of host publication | Nutrition and Food Grains |
Publisher | Elsevier Inc. |
Pages | 83-90 |
Number of pages | 8 |
Volume | 2-4 |
ISBN (Electronic) | 9780123947864 |
ISBN (Print) | 9780123944375 |
DOIs | |
State | Published - 17 Dec 2015 |
Externally published | Yes |
Keywords
- Celiac disease
- Cereals
- Diagnosis
- Epidemiology
- Genetics
- Gluten
- Gluten-free diet
- Immune response
- Small intestine
- Symptoms
- Therapy
- Toxicity