Celiac Disease

P. Koehler, H. Wieser, K. A. Scherf

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Celiac disease, with a prevalence of about 1% in many countries, is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten (storage proteins of wheat, rye, barley, and oats) in genetically susceptible individuals. Small-intestinal villous atrophy is the characteristic feature, and symptoms include diarrhea or steatorrhea and extraintestinal manifestations. A strict, lifelong gluten-free diet is the current essential therapy. The complex pathomechanism consists of incomplete gluten digestion, para- and transcellular passage of gluten peptides through the epithelium, and adaptive and innate immune responses in the lamina propria.

Original languageEnglish
Title of host publicationNutrition and Food Grains
PublisherElsevier Inc.
Pages83-90
Number of pages8
Volume2-4
ISBN (Electronic)9780123947864
ISBN (Print)9780123944375
DOIs
StatePublished - 17 Dec 2015
Externally publishedYes

Keywords

  • Celiac disease
  • Cereals
  • Diagnosis
  • Epidemiology
  • Genetics
  • Gluten
  • Gluten-free diet
  • Immune response
  • Small intestine
  • Symptoms
  • Therapy
  • Toxicity

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