CD8 T-cell subsets and viral load in the cerebrospinal fluid of therapy-naive HIV-infected individuals

Gloria Von Geldern; Sabine Cepok; Thorsten Nolting; Yihua Du; Verena Grummel; Ortwin Adams; Hans Peter Hartung; Gabriele Arendt; Bernhard Hemmer

doi:10.1097/QAD.0b013e328011ec76

CD8 T-cell subsets and viral load in the cerebrospinal fluid of therapy-naive HIV-infected individuals

Gloria Von Geldern, Sabine Cepok, Thorsten Nolting, Yihua Du, Verena Grummel, Ortwin Adams, Hans Peter Hartung, Gabriele Arendt, Bernhard Hemmer

Heinrich-Heine-University

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Central nervous system involvement is common in HIV infection. We determined the relationship between T-cell subsets and viral load in the cerebrospinal fluid (CSF) of therapy-naive, asymptomatic HIV-infected individuals. A shift from naive to effector-memory CD8 T cells was observed in the CSF of HIV-infected individuals compared with controls. The HIV load strongly correlated with CD8 T cells in CSF. Effector-memory CD8 T cells were positively and effector CD8 T cells were negatively associated with viral replication in CSF.

Original language	English
Pages (from-to)	250-253
Number of pages	4
Journal	AIDS
Volume	21
Issue number	2
DOIs	https://doi.org/10.1097/QAD.0b013e328011ec76
State	Published - Jan 2007
Externally published	Yes

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10.1097/QAD.0b013e328011ec76

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title = "CD8 T-cell subsets and viral load in the cerebrospinal fluid of therapy-naive HIV-infected individuals",

abstract = "Central nervous system involvement is common in HIV infection. We determined the relationship between T-cell subsets and viral load in the cerebrospinal fluid (CSF) of therapy-naive, asymptomatic HIV-infected individuals. A shift from naive to effector-memory CD8 T cells was observed in the CSF of HIV-infected individuals compared with controls. The HIV load strongly correlated with CD8 T cells in CSF. Effector-memory CD8 T cells were positively and effector CD8 T cells were negatively associated with viral replication in CSF.",

author = "Geldern, \{Gloria Von\} and Sabine Cepok and Thorsten Nolting and Yihua Du and Verena Grummel and Ortwin Adams and Hartung, \{Hans Peter\} and Gabriele Arendt and Bernhard Hemmer",

year = "2007",

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doi = "10.1097/QAD.0b013e328011ec76",

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T1 - CD8 T-cell subsets and viral load in the cerebrospinal fluid of therapy-naive HIV-infected individuals

AU - Geldern, Gloria Von

AU - Cepok, Sabine

AU - Nolting, Thorsten

AU - Du, Yihua

AU - Grummel, Verena

AU - Adams, Ortwin

AU - Hartung, Hans Peter

AU - Arendt, Gabriele

AU - Hemmer, Bernhard

PY - 2007/1

Y1 - 2007/1

N2 - Central nervous system involvement is common in HIV infection. We determined the relationship between T-cell subsets and viral load in the cerebrospinal fluid (CSF) of therapy-naive, asymptomatic HIV-infected individuals. A shift from naive to effector-memory CD8 T cells was observed in the CSF of HIV-infected individuals compared with controls. The HIV load strongly correlated with CD8 T cells in CSF. Effector-memory CD8 T cells were positively and effector CD8 T cells were negatively associated with viral replication in CSF.

AB - Central nervous system involvement is common in HIV infection. We determined the relationship between T-cell subsets and viral load in the cerebrospinal fluid (CSF) of therapy-naive, asymptomatic HIV-infected individuals. A shift from naive to effector-memory CD8 T cells was observed in the CSF of HIV-infected individuals compared with controls. The HIV load strongly correlated with CD8 T cells in CSF. Effector-memory CD8 T cells were positively and effector CD8 T cells were negatively associated with viral replication in CSF.

UR - https://www.scopus.com/pages/publications/33845954642

U2 - 10.1097/QAD.0b013e328011ec76

DO - 10.1097/QAD.0b013e328011ec76

M3 - Article

C2 - 17197822

AN - SCOPUS:33845954642

SN - 0269-9370

VL - 21

SP - 250

EP - 253

JO - AIDS

JF - AIDS

IS - 2

ER -

CD8 T-cell subsets and viral load in the cerebrospinal fluid of therapy-naive HIV-infected individuals

Abstract

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