@article{0ca59466ffb94019ae744041e4405862,
title = "CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions",
abstract = "CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response and establishing immunological tolerance. We report that in the normal human brain CCL19, but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in cerebrospinal fluid. In both active and inactive multiple sclerosis (MS) lesions CCL19 transcripts were elevated. In cerebrospinal fluid from MS and OIND patients CCL19 protein was increased. In relapsing-remitting and secondary progressive MS patients CCL19 correlated with intrathecal IgG production. This study suggests that CCL19 plays a role in both the physiological immunosurveillance of the healthy CNS and the pathological maintenance of immune cells in the CNS of MS patients.",
keywords = "CSF, Chemokines, ELISA, Immunosurveillance, Multiple sclerosis, Taqman",
author = "M. Krumbholz and D. Theil and F. Steinmeyer and S. Cepok and B. Hemmer and M. Hofbauer and C. Farina and T. Derfuss and A. Junker and T. Arzberger and I. Sinicina and C. Hartle and J. Newcombe and R. Hohlfeld and E. Meinl",
note = "Funding Information: We thank Prof. H. Lassmann for expert advice, Dr. P. Kivisakk and Prof. R. Ransohoff for valuable discussions, J. Benson, Drs. A. Fl{\"u}gel and D. Jenne for comments on the manuscript. We are grateful to the German Brain Bank {\textquoteleft}BrainNet{\textquoteright}, the UK Multiple Sclerosis Tissue Bank, and the Netherlands Brain Bank for providing autopsy tissue samples. BrainNet Germany is supported by a grant from the Federal Ministry of Health. The UK Multiple Sclerosis Tissue Bank is funded by the Multiple Sclerosis Society of Great Britain and Northern Ireland, registered charity 207495. This work was supported by the DFG (SFB 571, GRK 688, He 2386/5-1, TH 849), the Gemeinn{\"u}tzige Hertie-Foundation, the Deutsche Multiple Sklerose Gesellschaft, and the Verein zur Therapieforschung f{\"u}r MS-Kranke. The Institute for Clinical Neuroimmunology is supported by the Hermann and Lilly Schilling Foundation.",
year = "2007",
month = oct,
doi = "10.1016/j.jneuroim.2007.07.024",
language = "English",
volume = "190",
pages = "72--79",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier B.V.",
number = "1-2",
}
