TY - JOUR
T1 - CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells
AU - Günther, Claudia
AU - Bello-Fernandez, Concha
AU - Kopp, Tamara
AU - Kund, Julia
AU - Carballido-Perrig, Nicole
AU - Hinteregger, Sonja
AU - Fassl, Sandra
AU - Schwärzler, Christoph
AU - Lametschwandtner, Günther
AU - Stingl, Georg
AU - Biedermann, Tilo
AU - Carballido, José M.
PY - 2005/2/1
Y1 - 2005/2/1
N2 - CCL18 is a human chemokine secreted by monocytes and dendritic cells. The receptor for CCL18 is not yet known and the functions of this chemokine on immune cells are not fully elucidated. In this study, we describe that CCL18 is present in skin biopsies of atopic dermatitis (AD) patients but not in normal or psoriatic skin. CCL18 was specifically expressed by APCs in the dermis and by Langerhans and inflammatory dendritic epidermal cells in the epidermis. In addition, the serum levels of CCL18 and the percentages of CCL18-producing monocyte/macrophages and dendritic cells were significantly increased in AD patients compared with healthy controls. Furthermore, we demonstrate that CCL18 binds to CLA+ T cells in peripheral blood of AD patients and healthy individuals and induces migration of AD-derived memory T cells in vitro and in human skin-transplanted SCID mice. These findings highlight a unique role of CCL18 in AD and reveal a novel function of this chemokine mediating skin homing of a subpopulation of human memory T cells.
AB - CCL18 is a human chemokine secreted by monocytes and dendritic cells. The receptor for CCL18 is not yet known and the functions of this chemokine on immune cells are not fully elucidated. In this study, we describe that CCL18 is present in skin biopsies of atopic dermatitis (AD) patients but not in normal or psoriatic skin. CCL18 was specifically expressed by APCs in the dermis and by Langerhans and inflammatory dendritic epidermal cells in the epidermis. In addition, the serum levels of CCL18 and the percentages of CCL18-producing monocyte/macrophages and dendritic cells were significantly increased in AD patients compared with healthy controls. Furthermore, we demonstrate that CCL18 binds to CLA+ T cells in peripheral blood of AD patients and healthy individuals and induces migration of AD-derived memory T cells in vitro and in human skin-transplanted SCID mice. These findings highlight a unique role of CCL18 in AD and reveal a novel function of this chemokine mediating skin homing of a subpopulation of human memory T cells.
UR - http://www.scopus.com/inward/record.url?scp=19944432764&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.174.3.1723
DO - 10.4049/jimmunol.174.3.1723
M3 - Article
C2 - 15661937
AN - SCOPUS:19944432764
SN - 0022-1767
VL - 174
SP - 1723
EP - 1728
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -
