Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

Deepak Bararia; Johannes A. Hildebrand; Sebastian Stolz; Sarah Haebe; Stefan Alig; Christopher P. Trevisani; Francisco Osorio-Barrios; Michael D. Bartoschek; Michael Mentz; Alessandro Pastore; Erik Gaitzsch; Michael Heide; Vindi Jurinovic; Katharina Rautter; Jay Gunawardana; Muhammed B. Sabdia; Monika Szczepanowski; Julia Richter; Wolfram Klapper; Abner Louissaint; Christina Ludwig; Sebastian Bultmann; Heinrich Leonhardt; Sebastian Eustermann; Karl Peter Hopfner; Wolfgang Hiddemann; Michael von Bergwelt-Baildon; Christian Steidl; Robert Kridel; Joshua W.D. Tobin; Maher K. Gandhi; David M. Weinstock; Marc Schmidt-Supprian; Menyhárt B. Sárosi; Martina Rudelius; Verena Passerini; Josef Mautner; Oliver Weigert

doi:10.1016/j.celrep.2020.107522

Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

Deepak Bararia, Johannes A. Hildebrand, Sebastian Stolz, Sarah Haebe, Stefan Alig, Christopher P. Trevisani, Francisco Osorio-Barrios, Michael D. Bartoschek, Michael Mentz, Alessandro Pastore, Erik Gaitzsch, Michael Heide, Vindi Jurinovic, Katharina Rautter, Jay Gunawardana, Muhammed B. Sabdia, Monika Szczepanowski, Julia Richter, Wolfram Klapper, Abner LouissaintChristina Ludwig, Sebastian Bultmann, Heinrich Leonhardt, Sebastian Eustermann, Karl Peter Hopfner, Wolfgang Hiddemann, Michael von Bergwelt-Baildon, Christian Steidl, Robert Kridel, Joshua W.D. Tobin, Maher K. Gandhi, David M. Weinstock, Marc Schmidt-Supprian, Menyhárt B. Sárosi, Martina Rudelius, Verena Passerini, Josef Mautner, Oliver Weigert

Associate Professorship of Experimental Hematology

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Bararia et al. discover and functionally characterize a clinically relevant mechanism of tumor and immune cell interaction in follicular lymphoma, a prototypical type of blood cancer. Cathepsin S alterations result in aberrant hyperactivity of this lysosomal cysteine protease and induce a tumor-promoting CD4⁺ T cell enriched immune microenvironment.

Original language	English
Article number	107522
Journal	Cell Reports
Volume	31
Issue number	5
DOIs	https://doi.org/10.1016/j.celrep.2020.107522
State	Published - 5 May 2020

Keywords

T cell activation
antigen processing and presentation
cathepsin S
cysteine-protease
follicular lymphoma
immune microenvironment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2020.107522

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Bararia, D., Hildebrand, J. A., Stolz, S., Haebe, S., Alig, S., Trevisani, C. P., Osorio-Barrios, F., Bartoschek, M. D., Mentz, M., Pastore, A., Gaitzsch, E., Heide, M., Jurinovic, V., Rautter, K., Gunawardana, J., Sabdia, M. B., Szczepanowski, M., Richter, J., Klapper, W., ... Weigert, O. (2020). Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma. Cell Reports, 31(5), Article 107522. https://doi.org/10.1016/j.celrep.2020.107522

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title = "Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma",

abstract = "Bararia et al. discover and functionally characterize a clinically relevant mechanism of tumor and immune cell interaction in follicular lymphoma, a prototypical type of blood cancer. Cathepsin S alterations result in aberrant hyperactivity of this lysosomal cysteine protease and induce a tumor-promoting CD4+ T cell enriched immune microenvironment.",

keywords = "T cell activation, antigen processing and presentation, cathepsin S, cysteine-protease, follicular lymphoma, immune microenvironment",

author = "Deepak Bararia and Hildebrand, {Johannes A.} and Sebastian Stolz and Sarah Haebe and Stefan Alig and Trevisani, {Christopher P.} and Francisco Osorio-Barrios and Bartoschek, {Michael D.} and Michael Mentz and Alessandro Pastore and Erik Gaitzsch and Michael Heide and Vindi Jurinovic and Katharina Rautter and Jay Gunawardana and Sabdia, {Muhammed B.} and Monika Szczepanowski and Julia Richter and Wolfram Klapper and Abner Louissaint and Christina Ludwig and Sebastian Bultmann and Heinrich Leonhardt and Sebastian Eustermann and Hopfner, {Karl Peter} and Wolfgang Hiddemann and {von Bergwelt-Baildon}, Michael and Christian Steidl and Robert Kridel and Tobin, {Joshua W.D.} and Gandhi, {Maher K.} and Weinstock, {David M.} and Marc Schmidt-Supprian and S{\'a}rosi, {Menyh{\'a}rt B.} and Martina Rudelius and Verena Passerini and Josef Mautner and Oliver Weigert",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = may,

day = "5",

doi = "10.1016/j.celrep.2020.107522",

language = "English",

volume = "31",

journal = "Cell Reports",

issn = "2639-1856",

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Bararia, D, Hildebrand, JA, Stolz, S, Haebe, S, Alig, S, Trevisani, CP, Osorio-Barrios, F, Bartoschek, MD, Mentz, M, Pastore, A, Gaitzsch, E, Heide, M, Jurinovic, V, Rautter, K, Gunawardana, J, Sabdia, MB, Szczepanowski, M, Richter, J, Klapper, W, Louissaint, A, Ludwig, C, Bultmann, S, Leonhardt, H, Eustermann, S, Hopfner, KP, Hiddemann, W, von Bergwelt-Baildon, M, Steidl, C, Kridel, R, Tobin, JWD, Gandhi, MK, Weinstock, DM, Schmidt-Supprian, M, Sárosi, MB, Rudelius, M, Passerini, V, Mautner, J & Weigert, O 2020, 'Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma', Cell Reports, vol. 31, no. 5, 107522. https://doi.org/10.1016/j.celrep.2020.107522

TY - JOUR

T1 - Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

AU - Bararia, Deepak

AU - Hildebrand, Johannes A.

AU - Stolz, Sebastian

AU - Haebe, Sarah

AU - Alig, Stefan

AU - Trevisani, Christopher P.

AU - Osorio-Barrios, Francisco

AU - Bartoschek, Michael D.

AU - Mentz, Michael

AU - Pastore, Alessandro

AU - Gaitzsch, Erik

AU - Heide, Michael

AU - Jurinovic, Vindi

AU - Rautter, Katharina

AU - Gunawardana, Jay

AU - Sabdia, Muhammed B.

AU - Szczepanowski, Monika

AU - Richter, Julia

AU - Klapper, Wolfram

AU - Louissaint, Abner

AU - Ludwig, Christina

AU - Bultmann, Sebastian

AU - Leonhardt, Heinrich

AU - Eustermann, Sebastian

AU - Hopfner, Karl Peter

AU - Hiddemann, Wolfgang

AU - von Bergwelt-Baildon, Michael

AU - Steidl, Christian

AU - Kridel, Robert

AU - Tobin, Joshua W.D.

AU - Gandhi, Maher K.

AU - Weinstock, David M.

AU - Schmidt-Supprian, Marc

AU - Sárosi, Menyhárt B.

AU - Rudelius, Martina

AU - Passerini, Verena

AU - Mautner, Josef

AU - Weigert, Oliver

PY - 2020/5/5

Y1 - 2020/5/5

N2 - Bararia et al. discover and functionally characterize a clinically relevant mechanism of tumor and immune cell interaction in follicular lymphoma, a prototypical type of blood cancer. Cathepsin S alterations result in aberrant hyperactivity of this lysosomal cysteine protease and induce a tumor-promoting CD4+ T cell enriched immune microenvironment.

AB - Bararia et al. discover and functionally characterize a clinically relevant mechanism of tumor and immune cell interaction in follicular lymphoma, a prototypical type of blood cancer. Cathepsin S alterations result in aberrant hyperactivity of this lysosomal cysteine protease and induce a tumor-promoting CD4+ T cell enriched immune microenvironment.

KW - T cell activation

KW - antigen processing and presentation

KW - cathepsin S

KW - cysteine-protease

KW - follicular lymphoma

KW - immune microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85084139309&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.107522

DO - 10.1016/j.celrep.2020.107522

M3 - Article

C2 - 32330423

AN - SCOPUS:85084139309

SN - 2639-1856

VL - 31

JO - Cell Reports

JF - Cell Reports

IS - 5

M1 - 107522

ER -

Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma

Abstract

Keywords

UN SDGs

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