Cataract Induction by 1, 2-Naphthoquinone I. Studies on the Redox Properties of Bovine Lens Proteins

E. Kleber, R. Kröner, E. F. Elstner

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Conditions of oxidative stress may lead to cataract formation. Reaction of certain flavopro-teins, the NADH oxidoreductases with different quinones is well known to form hydrogen-peroxide. This reaction was investigated to get more information on cataract induction by naphthalene and its quinone metabolites. Protein extracts from bovine lens cortex exhibit “diaphorase” activity, indicated as dye reduction in the presence of NADH and dichloro-phenol-indophenol (DCPIP) or ferricyanide. Different redox cycling compounds are shown to be active in this “diaphorase” reaction by lens protein extract (LCE): Oxygen consumption can be detected in the presence of pyrroloquinoline quinone and juglone whereas 1, 4-naphtho-quinone. menadione and paraquat are no redox cyclists in this flavoprotein catalyzed reaction.

Original languageEnglish
Pages (from-to)280-284
Number of pages5
JournalZeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume46
Issue number3-4
DOIs
StatePublished - 1 Apr 1991

Keywords

  • Cataract
  • Naphthoquinone
  • Oxygen Activation
  • Redoxcycling

Fingerprint

Dive into the research topics of 'Cataract Induction by 1, 2-Naphthoquinone I. Studies on the Redox Properties of Bovine Lens Proteins'. Together they form a unique fingerprint.

Cite this