Catalytic N-Alkylation of Amines Using Carboxylic Acids and Molecular Hydrogen

Iván Sorribes, Jose R. Cabrero-Antonino, Cristian Vicent, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

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A convenient, practical and green N-alkylation of amines has been accomplished by applying readily available carboxylic acids in the presence of molecular hydrogen. Applying an in situ formed ruthenium/triphos complex and an organic acid as cocatalyst, a broad range of alkylated secondary and tertiary amines are obtained in good to excellent yields. This novel method is also successfully applied for the synthesis of unsymmetrically substituted N-methyl/alkyl anilines through a direct three-component coupling reaction of the corresponding amines, carboxylic acids, and CO2 as a C1 source.

Original languageEnglish
Pages (from-to)13580-13587
Number of pages8
JournalJournal of the American Chemical Society
Issue number42
StatePublished - 28 Oct 2015
Externally publishedYes


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