Catalytic enantioselective fluorination of β-ketoesters

Lukas Hintermann, Antonio Togni

Research output: Contribution to journalArticlepeer-review

366 Scopus citations

Abstract

Isolated and crystallized [Ti(TADDOLato)] complexes were used as catalysts for the first catalytic enantioselective (up to 90 % ee) C-F bond-forming reaction, the fluorination of β-ketoesters with the N-fluorotriethylenediammonium salt F-TEDA [Eq. (1)]. TADDOL=2,2-dimethyl-α,α,α',α'-tetraaryl-1,3-dioxolan-4,5-dimethanol.

Original languageEnglish
Pages (from-to)4359-4362
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume39
Issue number23
DOIs
StatePublished - 4 Dec 2000
Externally publishedYes

Keywords

  • Asymmetric catalysis
  • Fluorine
  • TADDOL
  • Titanium

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