Catalytic C-C bond formation through selective activation of C-F bonds

Volker P.W. Böhm, Christian W.K. Gstöttmayr, Thomas Weskamp, Wolfgang A. Herrmann

Research output: Contribution to journalArticlepeer-review

286 Scopus citations

Abstract

The activation of strong sp2 C-F bonds in catalytic C-C cross-coupling reactions with aryl Grignard reagents under mild conditions is possible: A nickel complex bearing an N-heterocyclic carbene ligand was identified as the most active catalyst for this reaction [Eq. (1)]. With the selective activation of aromatic C-F bonds over C-H bonds present, cross-coupling chemistry employing aryl halides has finally overcome its most challenging hurdle with regard to catalyst activity.

Original languageEnglish
Pages (from-to)3387-3389
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume40
Issue number18
DOIs
StatePublished - 17 Sep 2001

Keywords

  • Biaryls
  • C-C coupling
  • C-F activation
  • Carbene ligands
  • Homogeneous catalysis
  • Nickel

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