Catalytic amination of aldehydes to amides

Annegret Tillack, Ivo Rudloff, Matthias Beller

Research output: Contribution to journalArticlepeer-review

168 Scopus citations

Abstract

Aldehydes react in a disproportionation reaction in the presence of rhodium catalysts to yield amines and amides. By adding N-methylmorpholine N-oxide as an oxidant in the presence of catalytic amounts of rhodium, the oxidative amination of aldehydes proceeds selectively to give the corresponding amide. Both aliphatic and aromatic aldehydes react with secondary amines to yield carboxylic acid amides in good to excellent yields.

Original languageEnglish
Pages (from-to)523-528
Number of pages6
JournalEuropean Journal of Organic Chemistry
Issue number3
DOIs
StatePublished - Feb 2001
Externally publishedYes

Keywords

  • Aldehydes
  • Amides
  • Amination
  • Catalysis
  • Oxidation
  • Rhodium

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