Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination

Mihai Ancau; Friederike Liesche-Starnecker; Johanna Niederschweiberer; Sandro M. Krieg; Claus Zimmer; Charlotte Lingg; Daniela Kumpfmüller; Benno Ikenberg; Markus Ploner; Bernhard Hemmer; Silke Wunderlich; Mark Mühlau; Benjamin Knier

doi:10.3389/fneur.2021.820049

Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination

Mihai Ancau
, Friederike Liesche-Starnecker
, Johanna Niederschweiberer
, Sandro M. Krieg
, Claus Zimmer
, Charlotte Lingg
, Daniela Kumpfmüller
, Benno Ikenberg
, Markus Ploner
, Bernhard Hemmer
, Silke Wunderlich
, Mark Mühlau
, Benjamin Knier

Technical University of Munich
Munich Cluster for Systems Neurology (SyNergy)

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.

Original language	English
Article number	820049
Journal	Frontiers in Neurology
Volume	12
DOIs	https://doi.org/10.3389/fneur.2021.820049
State	Published - 2 Feb 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
ChAdOx1 nCoV-19
Weston-Hurst syndrome
acute disseminated encephalomyelitis
acute hemorrhagic encephalomyelitis
acute hemorrhagic leukoencephalitis
vaccination

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10.3389/fneur.2021.820049

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title = "Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination",

abstract = "We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.",

keywords = "COVID-19, ChAdOx1 nCoV-19, Weston-Hurst syndrome, acute disseminated encephalomyelitis, acute hemorrhagic encephalomyelitis, acute hemorrhagic leukoencephalitis, vaccination",

author = "Mihai Ancau and Friederike Liesche-Starnecker and Johanna Niederschweiberer and Krieg, \{Sandro M.\} and Claus Zimmer and Charlotte Lingg and Daniela Kumpfm{\"u}ller and Benno Ikenberg and Markus Ploner and Bernhard Hemmer and Silke Wunderlich and Mark M{\"u}hlau and Benjamin Knier",

note = "Publisher Copyright: Copyright {\textcopyright} 2022 Ancau, Liesche-Starnecker, Niederschweiberer, Krieg, Zimmer, Lingg, Kumpfm{\"u}ller, Ikenberg, Ploner, Hemmer, Wunderlich, M{\"u}hlau and Knier.",

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AU - Ancau, Mihai

AU - Liesche-Starnecker, Friederike

AU - Niederschweiberer, Johanna

AU - Krieg, Sandro M.

AU - Zimmer, Claus

AU - Lingg, Charlotte

AU - Kumpfmüller, Daniela

AU - Ikenberg, Benno

AU - Ploner, Markus

AU - Hemmer, Bernhard

AU - Wunderlich, Silke

AU - Mühlau, Mark

AU - Knier, Benjamin

PY - 2022/2/2

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AB - We present three cases fulfilling diagnostic criteria of hemorrhagic variants of acute disseminated encephalomyelitis (acute hemorrhagic encephalomyelitis, AHEM) occurring within 9 days after the first shot of ChAdOx1 nCoV-19. AHEM was diagnosed using magnetic resonance imaging, cerebrospinal fluid analysis and brain biopsy in one case. The close temporal association with the vaccination, the immune-related nature of the disease as well as the lack of other canonical precipitating factors suggested that AHEM was a vaccine-related adverse effect. We believe that AHEM might reflect a novel COVID-19 vaccine-related adverse event for which physicians should be vigilant and sensitized.

KW - COVID-19

KW - ChAdOx1 nCoV-19

KW - Weston-Hurst syndrome

KW - acute disseminated encephalomyelitis

KW - acute hemorrhagic encephalomyelitis

KW - acute hemorrhagic leukoencephalitis

KW - vaccination

UR - https://www.scopus.com/pages/publications/85124886724

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DO - 10.3389/fneur.2021.820049

M3 - Article

AN - SCOPUS:85124886724

SN - 1664-2295

VL - 12

JO - Frontiers in Neurology

JF - Frontiers in Neurology

M1 - 820049

ER -

Case Series: Acute Hemorrhagic Encephalomyelitis After SARS-CoV-2 Vaccination

Abstract

UN SDGs

Keywords

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