Cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides via palladium-catalyzed carbonylation reaction

Haoquan Li, Lin He, Helfried Neumann, Matthias Beller, Xiao Feng Wu

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

A cascade synthesis of quinazolinones from 2-aminobenzonitriles and aryl bromides through a palladium-catalyzed carbonylation reaction has been developed. Various quinazolinones were produced in moderate to excellent yields. The reactions go through aminocarbonylation of aryl bromides-hydration of nitriles-cyclization sequence. Notably, all the products were isolated by recrystallization.

Original languageEnglish
Pages (from-to)1336-1343
Number of pages8
JournalGreen Chemistry
Volume16
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

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