Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment

J. M. Castro-Lopes; I. Tavares; T. R. Tölle; A. Coimbra

doi:10.1016/0304-3959(94)90094-9

Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment

J. M. Castro-Lopes, I. Tavares, T. R. Tölle, A. Coimbra

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

An increase in the number of γ-aminobutyric acid (GABA)-immunorcactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection. The rise of GABAergic cells was restricted to the ipsilateral dorsal horn, reaching a peak value of 23.4% over the contralateral side 4 days after carrageenan injection. Sciatic neurectomy or neonatal capsaicin treatment prevented this effect. These findings suggest that dorsal horn GABA is up-regulated by the increase of noxious inflow conveyed by unmyelinated C fibers from the inflamed tissues.

Original language	English
Pages (from-to)	193-201
Number of pages	9
Journal	Pain
Volume	56
Issue number	2
DOIs	https://doi.org/10.1016/0304-3959(94)90094-9
State	Published - Feb 1994
Externally published	Yes

Keywords

(Rat)
Capsaicin
Carrageenan
Inflammatory pain
Spinal cord
γ-Aminobutyric acid

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10.1016/0304-3959(94)90094-9

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title = "Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment",

abstract = "An increase in the number of γ-aminobutyric acid (GABA)-immunorcactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection. The rise of GABAergic cells was restricted to the ipsilateral dorsal horn, reaching a peak value of 23.4% over the contralateral side 4 days after carrageenan injection. Sciatic neurectomy or neonatal capsaicin treatment prevented this effect. These findings suggest that dorsal horn GABA is up-regulated by the increase of noxious inflow conveyed by unmyelinated C fibers from the inflamed tissues.",

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author = "Castro-Lopes, {J. M.} and I. Tavares and T{\"o}lle, {T. R.} and A. Coimbra",

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AU - Castro-Lopes, J. M.

AU - Tavares, I.

AU - Tölle, T. R.

AU - Coimbra, A.

PY - 1994/2

Y1 - 1994/2

N2 - An increase in the number of γ-aminobutyric acid (GABA)-immunorcactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection. The rise of GABAergic cells was restricted to the ipsilateral dorsal horn, reaching a peak value of 23.4% over the contralateral side 4 days after carrageenan injection. Sciatic neurectomy or neonatal capsaicin treatment prevented this effect. These findings suggest that dorsal horn GABA is up-regulated by the increase of noxious inflow conveyed by unmyelinated C fibers from the inflamed tissues.

AB - An increase in the number of γ-aminobutyric acid (GABA)-immunorcactive cells is reported in the superficial dorsal horn of the rat spinal cord upon unilateral inflammation of the hind foot caused by subcutaneous carrageenan injection. The rise of GABAergic cells was restricted to the ipsilateral dorsal horn, reaching a peak value of 23.4% over the contralateral side 4 days after carrageenan injection. Sciatic neurectomy or neonatal capsaicin treatment prevented this effect. These findings suggest that dorsal horn GABA is up-regulated by the increase of noxious inflow conveyed by unmyelinated C fibers from the inflamed tissues.

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KW - Capsaicin

KW - Carrageenan

KW - Inflammatory pain

KW - Spinal cord

KW - γ-Aminobutyric acid

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Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment

Abstract

Keywords

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