Abstract
This study was designed to assess possible myocardial injury caused by interventional closure of atrial septal defects (ASDs) compared to diagnostic catheterization by measuring cardiac troponin I (cTn-I). Forty patients were enrolled; in 33 ASDs were successfully closed, while in 7 a diagnostic balloon sizing of the defect was performed only. Total cTn-I increased significantly from 0.1 to 1.9 μg/I at the end of the intervention and 2.23 at 4 hr and decreased to 1.35 at 15 hr. No significant increase could be detected in patients with diagnostic balloon sizing only or of CK/CK-MB levels either. Following interventional closure of ASDs with Amplatzer septum/PFO occluders, increased cTn-I levels for several hours indicate some transient, reversible myocardial membrane instability due to the device. Discrimination of ventricular myocardial infarction might be possible by estimating less sensitive CK and CK-MB levels only.
| Original language | English |
|---|---|
| Pages (from-to) | 124-129 |
| Number of pages | 6 |
| Journal | Catheterization and Cardiovascular Interventions |
| Volume | 58 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2003 |
| Externally published | Yes |
Keywords
- ASD
- Amplatzer PFO occluder
- Amplatzer septal occluder
- Cardiac enzyme
- Catheterization
- Myocardial damage