Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure

Angela Krackhardt; Stefan Schwartz; Agnieszka Korfel; Eckhard Thiel

doi:10.1080/10428199909169631

Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure

Angela Krackhardt, Stefan Schwartz, Agnieszka Korfel, Eckhard Thiel

Free University of Berlin

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A 79 year-old female patient presented with immunoblastic B-cell lymphoma of the ethmoidal sinuses and destruction of the anterior cranial fossa. After 3 cycles of high-dose methorexate (HD-MTX) MTX serum level remained elevated and creatinine serum levels raised. The patient received Carboxypeptidase G2 (CPG2) intravenously. Within one hour the MTX serum level decreased to < 1 μmol/l as determined by high pressure liquid chromatography (HPLC). The patient recovered without significant toxicity and attained a long lasting ongoing (> 14 months) complete remission. In this case we were able to demonstrate that rescue from HD-MT nephroroxicity by CPG2 is also safe and effective in patients with advanced age with impaired renal function. With the help of CPG2, sufficient and potentially curative therapy with HD-MTX may also be provided to patients with a high risk of renal failure.

Original language	English
Pages (from-to)	631-635
Number of pages	5
Journal	Leukemia and Lymphoma
Volume	35
Issue number	5-6
DOIs	https://doi.org/10.1080/10428199909169631
State	Published - 1999
Externally published	Yes

Keywords

Carboxypeptidase G2
Lymphoma
Methotrexate toxicity
Renal dysfunction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10428199909169631

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title = "Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure",

abstract = "A 79 year-old female patient presented with immunoblastic B-cell lymphoma of the ethmoidal sinuses and destruction of the anterior cranial fossa. After 3 cycles of high-dose methorexate (HD-MTX) MTX serum level remained elevated and creatinine serum levels raised. The patient received Carboxypeptidase G2 (CPG2) intravenously. Within one hour the MTX serum level decreased to < 1 μmol/l as determined by high pressure liquid chromatography (HPLC). The patient recovered without significant toxicity and attained a long lasting ongoing (> 14 months) complete remission. In this case we were able to demonstrate that rescue from HD-MT nephroroxicity by CPG2 is also safe and effective in patients with advanced age with impaired renal function. With the help of CPG2, sufficient and potentially curative therapy with HD-MTX may also be provided to patients with a high risk of renal failure.",

keywords = "Carboxypeptidase G2, Lymphoma, Methotrexate toxicity, Renal dysfunction",

author = "Angela Krackhardt and Stefan Schwartz and Agnieszka Korfel and Eckhard Thiel",

year = "1999",

doi = "10.1080/10428199909169631",

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T1 - Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure

AU - Krackhardt, Angela

AU - Schwartz, Stefan

AU - Korfel, Agnieszka

AU - Thiel, Eckhard

PY - 1999

Y1 - 1999

N2 - A 79 year-old female patient presented with immunoblastic B-cell lymphoma of the ethmoidal sinuses and destruction of the anterior cranial fossa. After 3 cycles of high-dose methorexate (HD-MTX) MTX serum level remained elevated and creatinine serum levels raised. The patient received Carboxypeptidase G2 (CPG2) intravenously. Within one hour the MTX serum level decreased to < 1 μmol/l as determined by high pressure liquid chromatography (HPLC). The patient recovered without significant toxicity and attained a long lasting ongoing (> 14 months) complete remission. In this case we were able to demonstrate that rescue from HD-MT nephroroxicity by CPG2 is also safe and effective in patients with advanced age with impaired renal function. With the help of CPG2, sufficient and potentially curative therapy with HD-MTX may also be provided to patients with a high risk of renal failure.

AB - A 79 year-old female patient presented with immunoblastic B-cell lymphoma of the ethmoidal sinuses and destruction of the anterior cranial fossa. After 3 cycles of high-dose methorexate (HD-MTX) MTX serum level remained elevated and creatinine serum levels raised. The patient received Carboxypeptidase G2 (CPG2) intravenously. Within one hour the MTX serum level decreased to < 1 μmol/l as determined by high pressure liquid chromatography (HPLC). The patient recovered without significant toxicity and attained a long lasting ongoing (> 14 months) complete remission. In this case we were able to demonstrate that rescue from HD-MT nephroroxicity by CPG2 is also safe and effective in patients with advanced age with impaired renal function. With the help of CPG2, sufficient and potentially curative therapy with HD-MTX may also be provided to patients with a high risk of renal failure.

KW - Carboxypeptidase G2

KW - Lymphoma

KW - Methotrexate toxicity

KW - Renal dysfunction

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DO - 10.1080/10428199909169631

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SN - 1042-8194

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JO - Leukemia and Lymphoma

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ER -

Carboxypeptidase G2 rescue in a 79 year-old patient with cranial lymphoma after high-dose methotrexate induced acute renal failure

Abstract

Keywords

UN SDGs

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