Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides

Elisabeth Lohof, Eckart Planker, Christian Mang, Fred Burkhart, Michael A. Dechantsreiter, Roland Haubner, Hans Jürgen Wester, Markus Schwaiger, Günther Hölzemann, Simon L. Goodman, Horst Kessler

Research output: Contribution to journalArticlepeer-review

144 Scopus citations


To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.

Original languageEnglish
Pages (from-to)2761-2764
Number of pages4
JournalAngewandte Chemie International Edition in English
Issue number15
StatePublished - 4 Aug 2000


  • Carbohydrates
  • Drug design
  • Integrins
  • Peptidomimetics


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