Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides

Elisabeth Lohof; Eckart Planker; Christian Mang; Fred Burkhart; Michael A. Dechantsreiter; Roland Haubner; Hans Jürgen Wester; Markus Schwaiger; Günther Hölzemann; Simon L. Goodman; Horst Kessler

doi:10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides

Elisabeth Lohof, Eckart Planker, Christian Mang, Fred Burkhart, Michael A. Dechantsreiter, Roland Haubner, Hans Jürgen Wester, Markus Schwaiger, Günther Hölzemann, Simon L. Goodman, Horst Kessler

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Abstract

To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.

Original language	English
Pages (from-to)	2761-2764
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	39
Issue number	15
DOIs	https://doi.org/10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9
State	Published - 4 Aug 2000

Keywords

Carbohydrates
Drug design
Integrins
Peptidomimetics

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10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

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Lohof, E., Planker, E., Mang, C., Burkhart, F., Dechantsreiter, M. A., Haubner, R., Wester, H. J., Schwaiger, M., Hölzemann, G., Goodman, S. L., & Kessler, H. (2000). Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides. Angewandte Chemie International Edition in English, 39(15), 2761-2764. https://doi.org/10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

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abstract = "To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.",

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Lohof, E, Planker, E, Mang, C, Burkhart, F, Dechantsreiter, MA, Haubner, R, Wester, HJ , Schwaiger, M, Hölzemann, G, Goodman, SL & Kessler, H 2000, 'Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides', Angewandte Chemie International Edition in English, vol. 39, no. 15, pp. 2761-2764. https://doi.org/10.1002/1521-3773(20000804)39:15<2761::AID-ANIE2761>3.0.CO;2-9

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T2 - Cyclic α(v)-selective RGD peptides

AU - Lohof, Elisabeth

AU - Planker, Eckart

AU - Mang, Christian

AU - Burkhart, Fred

AU - Dechantsreiter, Michael A.

AU - Haubner, Roland

AU - Wester, Hans Jürgen

AU - Schwaiger, Markus

AU - Hölzemann, Günther

AU - Goodman, Simon L.

AU - Kessler, Horst

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N2 - To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.

AB - To improve pharmacokinetic and -dynamic properties of peptidic, bioactive compounds they can be derivatized with carbohydrate building blocks. By incorporation into the peptidic backbone (see for example 1) the conformation of the pharmacophoric moieties can be influenced, while derivatization of side chains (see for example 2) mainly modifies the pharmacokinetic behavior.

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KW - Drug design

KW - Integrins

KW - Peptidomimetics

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ER -

Carbohydrate derivatives for use in drug design: Cyclic α(v)-selective RGD peptides

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Keywords

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