Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation

Yoshiteru Sasaki, Emmanuel Derudder, Elias Hobeika, Roberta Pelanda, Michael Reth, Klaus Rajewsky, Marc Schmidt-Supprian

Research output: Contribution to journalArticlepeer-review

266 Scopus citations

Abstract

The maintenance of mature B cells hinges on signals emitted from the BAFF-R cell-surface receptor, but the nature of these signals is incompletely understood. Inhibition of canonical NF-κB transcription factor activity through ablation of the essential scaffold protein NEMO arrests B cell development at the same stage as BAFF-R deficiency. Correspondingly, activation of this pathway by constitutively active IκB Kinase2 renders B cell survival independent of BAFF-R:BAFF interactions and prevents proapoptotic PKCδ nuclear translocation. In addition, canonical NF-κB activity mediates differentiation and proper localization of follicular and marginal zone B cells in the absence of BAFF-R, but not CD19. By replacing BAFF-R signals, constitutive canonical NF-κB signaling, a hallmark of various B cell lymphomas, causes accumulation of resting B cells and promotes their proliferation and survival upon activation, but does not per se induce lymphomagenesis. Therefore, canonical NF-κB activity can substitute for BAFF-R signals in B cell development and pathogenesis.

Original languageEnglish
Pages (from-to)729-739
Number of pages11
JournalImmunity
Volume24
Issue number6
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • MOLIMMUNO
  • SIGNALING

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