Canonical correlation analysis of sub-cortical brain structures using non-rigid registration

Anil Rao, Kola Babalola, Daniel Rueckert

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Scopus citations

Abstract

In this paper, we present the application of canonical correlation analysis to investigate how the shapes of different structures within the brain vary statistically relative to each other. Canonical correlation analysis is a multivariate statistical technique which extracts and quantifies correlated behaviour between two sets of vector variables. Firstly, we perform non-rigid image registration of 93 sets of 3D MR images to build sets of surfaces and correspondences for sub-cortical structures in the brain. Canonical correlation analysis is then used to extract and quantify correlated behaviour in the shapes of each pair of surfaces. The results show that correlations are strongest between neighbouring structures and reveal symmetry in the correlation strengths for the left and right sides of the brain.

Original languageEnglish
Title of host publicationBiomedical Image Registration - Third International Workshop, WBIR 2006, Proceedings
PublisherSpringer Verlag
Pages66-74
Number of pages9
ISBN (Print)3540356487, 9783540356486
DOIs
StatePublished - 2006
Externally publishedYes
Event3rd International Workshop on Biomedical Image Registration, WBIR 2006 - Utrecht, Netherlands
Duration: 9 Jul 200611 Jul 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4057 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference3rd International Workshop on Biomedical Image Registration, WBIR 2006
Country/TerritoryNetherlands
CityUtrecht
Period9/07/0611/07/06

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