TY - JOUR
T1 - Cancer of the ovary, fallopian tube, and peritoneum
T2 - a population-based comparison of the prognostic factors and outcomes
AU - Rottmann, Miriam
AU - Burges, A.
AU - Mahner, S.
AU - Anthuber, C.
AU - Beck, T.
AU - Grab, D.
AU - Schnelzer, A.
AU - Kiechle, M.
AU - Mayr, D.
AU - Pölcher, M.
AU - Schubert-Fritschle, G.
AU - Engel, J.
N1 - Publisher Copyright:
© 2017, Springer-Verlag Berlin Heidelberg.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Purpose: The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. Methods: We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of the Munich Cancer Registry (meanwhile 4.8 million inhabitants). Tumour site differences were examined by comparing prognostic factors, treatments, the time to progression, and survival. The effect of the tumour site was additionally analysed by a Cox regression model. Results: The median age at diagnosis, histology, and FIGO stage significantly differed among the tumour sites (p < 0.001); PC patients were older, more often diagnosed with a serous subtype, and in FIGO stage III or IV. The time to progression and survival significantly differed among the tumour sites. When stratified by FIGO stage, the differences in time to progression disappeared, and the differences in survival considerably weakened. The differences in the multivariate survival analysis showed an almost identical outcome in PC patients (HR 1.07 [0.91–1.25]) and an improved survival of FC patients (HR 0.63 [0.49–0.81]) compared to that of OC patients. Conclusion: The comparison of OC, FC, and PC patients in this large-scale population-based study showed differences in the prognostic factors. These differences primarily account for the inferior outcome of PC patients, and for the improved survival of FC compared to OC patients.
AB - Purpose: The objective was to compare the prognostic factors and outcomes among primary ovarian cancer (OC), fallopian tube cancer (FC), and peritoneal cancer (PC) patients in a population-based setting. Methods: We analysed 5399 OC, 327 FC, and 416 PC patients diagnosed between 1998 and 2014 in the catchment area of the Munich Cancer Registry (meanwhile 4.8 million inhabitants). Tumour site differences were examined by comparing prognostic factors, treatments, the time to progression, and survival. The effect of the tumour site was additionally analysed by a Cox regression model. Results: The median age at diagnosis, histology, and FIGO stage significantly differed among the tumour sites (p < 0.001); PC patients were older, more often diagnosed with a serous subtype, and in FIGO stage III or IV. The time to progression and survival significantly differed among the tumour sites. When stratified by FIGO stage, the differences in time to progression disappeared, and the differences in survival considerably weakened. The differences in the multivariate survival analysis showed an almost identical outcome in PC patients (HR 1.07 [0.91–1.25]) and an improved survival of FC patients (HR 0.63 [0.49–0.81]) compared to that of OC patients. Conclusion: The comparison of OC, FC, and PC patients in this large-scale population-based study showed differences in the prognostic factors. These differences primarily account for the inferior outcome of PC patients, and for the improved survival of FC compared to OC patients.
KW - Cancer registry
KW - Fallopian tube cancer
KW - Ovarian cancer
KW - Peritoneal cancer
KW - Prognostic factors
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85018360433&partnerID=8YFLogxK
U2 - 10.1007/s00432-017-2422-6
DO - 10.1007/s00432-017-2422-6
M3 - Article
C2 - 28447160
AN - SCOPUS:85018360433
SN - 0171-5216
VL - 143
SP - 1833
EP - 1844
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
IS - 9
ER -
