Cancer neuroscience: State of the field, emerging directions

Frank Winkler; Humsa S. Venkatesh; Moran Amit; Tracy Batchelor; Ihsan Ekin Demir; Benjamin Deneen; David H. Gutmann; Shawn Hervey-Jumper; Thomas Kuner; Donald Mabbott; Michael Platten; Asya Rolls; Erica K. Sloan; Timothy C. Wang; Wolfgang Wick; Varun Venkataramani; Michelle Monje

doi:10.1016/j.cell.2023.02.002

Cancer neuroscience: State of the field, emerging directions

Frank Winkler
, Humsa S. Venkatesh
, Moran Amit
, Tracy Batchelor
, Ihsan Ekin Demir
, Benjamin Deneen
, David H. Gutmann
, Shawn Hervey-Jumper
, Thomas Kuner
, Donald Mabbott
, Michael Platten
, Asya Rolls
, Erica K. Sloan
, Timothy C. Wang
, Wolfgang Wick
, Varun Venkataramani
, Michelle Monje

Department of Surgery

University Hospital Heidelberg
Brigham and Women's Hospital
University of Texas Graduate School of Biomedical Sciences at Houston
Baylor College of Medicine
Washington University School of Medicine in St. Louis
University of California San Francisco
Heidelberg University
Hospital for Sick Children and University of Toronto
Heidelberg University
Technion - Israel Institute of Technology
Monash University
Columbia University
Stanford University

Research output: Contribution to journal › Review article › peer-review

393 Scopus citations

Abstract

The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.

Original language	English
Pages (from-to)	1689-1707
Number of pages	19
Journal	Cell
Volume	186
Issue number	8
DOIs	https://doi.org/10.1016/j.cell.2023.02.002
State	Published - 13 Apr 2023

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SDG 3 Good Health and Well-being

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10.1016/j.cell.2023.02.002

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Winkler, F., Venkatesh, H. S., Amit, M., Batchelor, T., Demir, I. E., Deneen, B., Gutmann, D. H., Hervey-Jumper, S., Kuner, T., Mabbott, D., Platten, M., Rolls, A., Sloan, E. K., Wang, T. C., Wick, W., Venkataramani, V., & Monje, M. (2023). Cancer neuroscience: State of the field, emerging directions. Cell, 186(8), 1689-1707. https://doi.org/10.1016/j.cell.2023.02.002

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title = "Cancer neuroscience: State of the field, emerging directions",

abstract = "The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.",

author = "Frank Winkler and Venkatesh, \{Humsa S.\} and Moran Amit and Tracy Batchelor and Demir, \{Ihsan Ekin\} and Benjamin Deneen and Gutmann, \{David H.\} and Shawn Hervey-Jumper and Thomas Kuner and Donald Mabbott and Michael Platten and Asya Rolls and Sloan, \{Erica K.\} and Wang, \{Timothy C.\} and Wolfgang Wick and Varun Venkataramani and Michelle Monje",

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T2 - State of the field, emerging directions

AU - Winkler, Frank

AU - Venkatesh, Humsa S.

AU - Amit, Moran

AU - Batchelor, Tracy

AU - Demir, Ihsan Ekin

AU - Deneen, Benjamin

AU - Gutmann, David H.

AU - Hervey-Jumper, Shawn

AU - Kuner, Thomas

AU - Mabbott, Donald

AU - Platten, Michael

AU - Rolls, Asya

AU - Sloan, Erica K.

AU - Wang, Timothy C.

AU - Wick, Wolfgang

AU - Venkataramani, Varun

AU - Monje, Michelle

PY - 2023/4/13

Y1 - 2023/4/13

N2 - The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.

AB - The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.

UR - https://www.scopus.com/pages/publications/85151566808

U2 - 10.1016/j.cell.2023.02.002

DO - 10.1016/j.cell.2023.02.002

M3 - Review article

C2 - 37059069

AN - SCOPUS:85151566808

SN - 0092-8674

VL - 186

SP - 1689

EP - 1707

JO - Cell

JF - Cell

IS - 8

ER -

Cancer neuroscience: State of the field, emerging directions

Abstract

UN SDGs

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