Caesarean Section has no impact on lung function at the age of 15 years

Irene Brüske, Zhengcun Pei, Elisabeth Thiering, Claudia Flexeder, Dietrich Berdel, Andrea Von Berg, Sibylle Koletzko, Carl Peter Bauer, Barbara Hoffmann, Joachim Heinrich, Holger Schulz

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Summary Background Epidemiological studies and meta-analyses have shown an increased risk of childhood asthma for children born by Caesarean Section (C-Section). Objective To investigate the effect of delivery by C-Section on lung function and asthma in adolescence in a population-based prospective birth cohort of healthy full term newborns. Methods Questionnaire data on mode of delivery and asthma as well as spirometric measurements were available for 1850 adolescents at the age of 15 years, who participated in a follow-up examination of the GINIplus study. Linear regression models were used to examine associations between mode of delivery and lung function parameters. Two reference populations (Lunokid and GLI) were used to calculate the standardized z-scores of lung function parameters. Results The mean difference in lung function parameters for adolescents born by C-Section, compared to vaginal delivery was not statistically significant. The risk for developing asthma by the age of 15 years was not higher in children born by C-Section - OR: 0.87 (95% CI: 0.57, 1.33) adjusted for sex, age, study center, and parental education level. Conclusion C-Section was not associated with impaired lung function or an increased risk of asthma at the age of 15 years in our birth cohort of healthy full term neonates. Pediatr Pulmonol. 2015; 50:1262-1269.

Original languageEnglish
Pages (from-to)1262-1269
Number of pages8
JournalPediatric Pulmonology
Volume50
Issue number12
DOIs
StatePublished - 1 Dec 2015

Keywords

  • C-Section
  • asthma
  • lung function

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