C-reactive protein-albumin ratio is an independent prognostic predictor of tumor recurrence in stage IIIA-N2 lung adenocarcinoma patients

Yoshikane Yamauchi, Seyer Safi, Thomas Muley, Arne Warth, Felix J.F. Herth, Hendrik Dienemann, Hans Hoffmann, Martin E. Eichhorn

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Objective To systematically evaluate the prognostic value of nutrition/inflammation-based markers for recurrence-free survival (RFS) in pN2-stage IIIA lung adenocarcinoma patients. Materials and methods Data from 156 patients who had pathologically confirmed pN2-stage IIIA primary lung adenocarcinoma and received complete surgical resection from 2010 to 2014 were retrospectively analyzed. The data for Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS, C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and prognostic nutritional index were analyzed. Univariate and multivariate Cox proportional-hazards regression analyses were used to identify the prognostic factors associated with RFS. Results The optimal cutoff value for the CAR was set at 0.6. A significant correlation was found between the CAR and RFS (P = 0.001) by univariate analysis. Multivariate analysis between RFS and the factors selected from univariate analysis showed that ECOG performance status, pneumonectomy, multi-level N2, and high CAR were independent predictors of RFS. Conclusion The CAR was the best prognostic marker to predict tumor recurrence in pN2-stage IIIA lung adenocarcinoma patients among the 7 nutrition/inflammation-based markers. The preoperative CAR may identify patients with a high risk of postoperative tumor recurrence.

Original languageEnglish
Pages (from-to)62-67
Number of pages6
JournalLung Cancer
Volume114
DOIs
StatePublished - Dec 2017
Externally publishedYes

Keywords

  • C-reactive protein-albumin ratio
  • Inflammation
  • Lung adenocarcinoma
  • NSCLC stage IIIA
  • Nutrition
  • Prognostic marker

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