Abstract
A patient with a 12‐year history of a relapsing bullous dermatosis is presented. Unusual clinical features included urticarial erythema, conspicuous mottled hyper‐ and depigmentation, lichenification and ichthyosiform hyperkeratosis. Serum immunoglobulin E levels were elevated. Histological examination showing deposits of amyloid in the uppermost dermis confirmed the diagnosis of bullous amyloidosis. Ultrastructurally, blister formation occurred at the level of the lamina lucida. The amyloid did not react with a panel of antibodies directed against amyloid fibril proteins. No underlying systemic disease was found. The bullous eruption responded to prednisolone therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 85-95 |
| Number of pages | 11 |
| Journal | British Journal of Dermatology |
| Volume | 113 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 1985 |
| Externally published | Yes |