Brown adipose tissue harbors a distinct sub-population of regulatory T cells

Dasa Medrikova; Tjeerd P. Sijmonsma; Katharina Sowodniok; David M. Richards; Michael Delacher; Carsten Sticht; Norbert Gretz; Tobias Schafmeier; Markus Feuerer; Stephan Herzig

doi:10.1371/journal.pone.0118534

Brown adipose tissue harbors a distinct sub-population of regulatory T cells

Dasa Medrikova
, Tjeerd P. Sijmonsma
, Katharina Sowodniok
, David M. Richards
, Michael Delacher
, Carsten Sticht
, Norbert Gretz
, Tobias Schafmeier
, Markus Feuerer
, Stephan Herzig

Heidelberg University
German Cancer Research Center
Universitätsmedizin Mannheim
Helmholtz Zentrum München German Research Center for Environmental Health
University Hospital Heidelberg

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

Regulatory T (T _reg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of T_reg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of T_reg cells characterized by a unique gene signature. As these T_reg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific T_reg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

Original language	English
Article number	e0118534
Journal	PLoS ONE
Volume	10
Issue number	2
DOIs	https://doi.org/10.1371/journal.pone.0118534
State	Published - 25 Feb 2015
Externally published	Yes

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title = "Brown adipose tissue harbors a distinct sub-population of regulatory T cells",

abstract = "Regulatory T (T reg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.",

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AU - Medrikova, Dasa

AU - Sijmonsma, Tjeerd P.

AU - Sowodniok, Katharina

AU - Richards, David M.

AU - Delacher, Michael

AU - Sticht, Carsten

AU - Gretz, Norbert

AU - Schafmeier, Tobias

AU - Feuerer, Markus

AU - Herzig, Stephan

PY - 2015/2/25

Y1 - 2015/2/25

N2 - Regulatory T (T reg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

AB - Regulatory T (T reg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.

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JF - PLoS ONE

IS - 2

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ER -

Brown adipose tissue harbors a distinct sub-population of regulatory T cells

Abstract

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