TY - JOUR
T1 - Brown adipose tissue harbors a distinct sub-population of regulatory T cells
AU - Medrikova, Dasa
AU - Sijmonsma, Tjeerd P.
AU - Sowodniok, Katharina
AU - Richards, David M.
AU - Delacher, Michael
AU - Sticht, Carsten
AU - Gretz, Norbert
AU - Schafmeier, Tobias
AU - Feuerer, Markus
AU - Herzig, Stephan
N1 - Publisher Copyright:
© 2015 Medrikova et al.
PY - 2015/2/25
Y1 - 2015/2/25
N2 - Regulatory T (T reg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.
AB - Regulatory T (T reg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue (BAT). Indeed, BAT harbored a unique sub-set of Treg cells characterized by a unique gene signature. As these Treg cells respond to BAT activation upon cold exposure, this study defines a BAT-specific Treg sub-set with direct implications for the regulation of energy homeostasis in response to environmental stress.
UR - https://www.scopus.com/pages/publications/84923797462
U2 - 10.1371/journal.pone.0118534
DO - 10.1371/journal.pone.0118534
M3 - Article
C2 - 25714366
AN - SCOPUS:84923797462
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 2
M1 - e0118534
ER -