Bronchopulmonary C-fibers modulate the breathing pattern in surfactant-depleted juvenile cats

Esther Rieger-Fackeldey; Richard Sindelar; Gunnar Sedin; Anders Jonzon

doi:10.1016/j.resp.2007.10.017

Bronchopulmonary C-fibers modulate the breathing pattern in surfactant-depleted juvenile cats

Esther Rieger-Fackeldey
, Richard Sindelar
, Gunnar Sedin
, Anders Jonzon

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The aim of this study was to investigate the influence of nonmyelinated C-fibers on the breathing pattern by cooling the vagal nerves to temperatures at which myelinated nerve transmission from pulmonary stretch receptors is blocked (+7 °C) and further at which nonmyelinated fiber input is blocked (0 °C), in anaesthetized spontaneously breathing juvenile cats with normal (L_N), surfactant-depleted (L_D) and surfactant-treated (L_T) lungs. In L_N, vagal cooling from +7 to 0 °C decreased respiratory frequency (f_R; -8%; p < 0.01), and increased tidal volume (V_T; +40%; p < 0.01). In the presence of shallow fast breathing in L_D, f_R decreased (+38 to +7 °C: -26%; p < 0.015 and +7 to 0 °C: -24%; p < 0.001) and V_T increased (+37%; p < 0.049 and +88%; p < 0.016). In L_T, f_R decreased (+7 to 0 °C: -21%; p < 0.001), whereas V_T remained the same at 0 °C (+12%; NS). These findings show for the first time that the activity of bronchopulmonary C-fibers have a prominent role in modulating the breathing pattern in juvenile cats with surfactant-depleted lungs.

Original language	English
Pages (from-to)	341-349
Number of pages	9
Journal	Respiratory Physiology and Neurobiology
Volume	160
Issue number	3
DOIs	https://doi.org/10.1016/j.resp.2007.10.017
State	Published - 29 Feb 2008
Externally published	Yes

Keywords

Control of breathing
Pulmonary C-fiber
Pulmonary stretch receptors
Surfactant-depletion
Vagal cooling

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10.1016/j.resp.2007.10.017

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title = "Bronchopulmonary C-fibers modulate the breathing pattern in surfactant-depleted juvenile cats",

abstract = "The aim of this study was to investigate the influence of nonmyelinated C-fibers on the breathing pattern by cooling the vagal nerves to temperatures at which myelinated nerve transmission from pulmonary stretch receptors is blocked (+7 °C) and further at which nonmyelinated fiber input is blocked (0 °C), in anaesthetized spontaneously breathing juvenile cats with normal (LN), surfactant-depleted (LD) and surfactant-treated (LT) lungs. In LN, vagal cooling from +7 to 0 °C decreased respiratory frequency (fR; -8\%; p < 0.01), and increased tidal volume (VT; +40\%; p < 0.01). In the presence of shallow fast breathing in LD, fR decreased (+38 to +7 °C: -26\%; p < 0.015 and +7 to 0 °C: -24\%; p < 0.001) and VT increased (+37\%; p < 0.049 and +88\%; p < 0.016). In LT, fR decreased (+7 to 0 °C: -21\%; p < 0.001), whereas VT remained the same at 0 °C (+12\%; NS). These findings show for the first time that the activity of bronchopulmonary C-fibers have a prominent role in modulating the breathing pattern in juvenile cats with surfactant-depleted lungs.",

keywords = "Control of breathing, Pulmonary C-fiber, Pulmonary stretch receptors, Surfactant-depletion, Vagal cooling",

author = "Esther Rieger-Fackeldey and Richard Sindelar and Gunnar Sedin and Anders Jonzon",

note = "Funding Information: The authors are indebted to Barbro Kj{\"a}llstr{\"o}m for excellent laboratory assistance. This study was financially supported by grants from the Swedish Research Council (72X-04998); Her Royal Highness The Crown Princess Lovisa's Foundation for Children's Health Care, Stockholm; Habilitationsstipendium, Hochschul- und Wissenschaftsprogramm des Bundes und der L{\"a}nder, Germany.",

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AU - Rieger-Fackeldey, Esther

AU - Sindelar, Richard

AU - Sedin, Gunnar

AU - Jonzon, Anders

N1 - Funding Information: The authors are indebted to Barbro Kjällström for excellent laboratory assistance. This study was financially supported by grants from the Swedish Research Council (72X-04998); Her Royal Highness The Crown Princess Lovisa's Foundation for Children's Health Care, Stockholm; Habilitationsstipendium, Hochschul- und Wissenschaftsprogramm des Bundes und der Länder, Germany.

PY - 2008/2/29

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N2 - The aim of this study was to investigate the influence of nonmyelinated C-fibers on the breathing pattern by cooling the vagal nerves to temperatures at which myelinated nerve transmission from pulmonary stretch receptors is blocked (+7 °C) and further at which nonmyelinated fiber input is blocked (0 °C), in anaesthetized spontaneously breathing juvenile cats with normal (LN), surfactant-depleted (LD) and surfactant-treated (LT) lungs. In LN, vagal cooling from +7 to 0 °C decreased respiratory frequency (fR; -8%; p < 0.01), and increased tidal volume (VT; +40%; p < 0.01). In the presence of shallow fast breathing in LD, fR decreased (+38 to +7 °C: -26%; p < 0.015 and +7 to 0 °C: -24%; p < 0.001) and VT increased (+37%; p < 0.049 and +88%; p < 0.016). In LT, fR decreased (+7 to 0 °C: -21%; p < 0.001), whereas VT remained the same at 0 °C (+12%; NS). These findings show for the first time that the activity of bronchopulmonary C-fibers have a prominent role in modulating the breathing pattern in juvenile cats with surfactant-depleted lungs.

AB - The aim of this study was to investigate the influence of nonmyelinated C-fibers on the breathing pattern by cooling the vagal nerves to temperatures at which myelinated nerve transmission from pulmonary stretch receptors is blocked (+7 °C) and further at which nonmyelinated fiber input is blocked (0 °C), in anaesthetized spontaneously breathing juvenile cats with normal (LN), surfactant-depleted (LD) and surfactant-treated (LT) lungs. In LN, vagal cooling from +7 to 0 °C decreased respiratory frequency (fR; -8%; p < 0.01), and increased tidal volume (VT; +40%; p < 0.01). In the presence of shallow fast breathing in LD, fR decreased (+38 to +7 °C: -26%; p < 0.015 and +7 to 0 °C: -24%; p < 0.001) and VT increased (+37%; p < 0.049 and +88%; p < 0.016). In LT, fR decreased (+7 to 0 °C: -21%; p < 0.001), whereas VT remained the same at 0 °C (+12%; NS). These findings show for the first time that the activity of bronchopulmonary C-fibers have a prominent role in modulating the breathing pattern in juvenile cats with surfactant-depleted lungs.

KW - Control of breathing

KW - Pulmonary C-fiber

KW - Pulmonary stretch receptors

KW - Surfactant-depletion

KW - Vagal cooling

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JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

IS - 3

ER -

Bronchopulmonary C-fibers modulate the breathing pattern in surfactant-depleted juvenile cats

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Keywords

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