TY - JOUR
T1 - Breath indeed carries significant information about a disease
T2 - Potential biomarkers of cerebral palsy
AU - Maiti, Kiran Sankar
AU - Roy, Susmita
AU - Lampe, Renée
AU - Apolonski, Alexander
N1 - Publisher Copyright:
© 2020 The Authors. Journal of Biophotonics published by WILEY-VCH GmbH
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Objective and reliable noninvasive medical diagnostics of a large variety of diseases is still a dream. As a step in the direction of realization, a spectroscopic breath study of cerebral palsy (CP) was performed. Principal component analysis revealed data clustering for a healthy group and CP individuals was observed, with a P-value below 10−5. Learning algorithms resulted in 91% accuracy in distinguishing the groups. With the help of manual analysis of absorption spectral features of breath samples, two volatile organic compounds were identified that demonstrate significant deviations in the groups. These represent two esters of propionic acid (PPAE). A transportation scheme was hypothesized that links the gut where propionic acid (PPA) and PPAE are produced, the brain of CP patients, through which PPA and PPAE transmit, and the lungs where PPAE releases. The results show a possibility to detect one more brain-related disorder via breath, in this case CP.
AB - Objective and reliable noninvasive medical diagnostics of a large variety of diseases is still a dream. As a step in the direction of realization, a spectroscopic breath study of cerebral palsy (CP) was performed. Principal component analysis revealed data clustering for a healthy group and CP individuals was observed, with a P-value below 10−5. Learning algorithms resulted in 91% accuracy in distinguishing the groups. With the help of manual analysis of absorption spectral features of breath samples, two volatile organic compounds were identified that demonstrate significant deviations in the groups. These represent two esters of propionic acid (PPAE). A transportation scheme was hypothesized that links the gut where propionic acid (PPA) and PPAE are produced, the brain of CP patients, through which PPA and PPAE transmit, and the lungs where PPAE releases. The results show a possibility to detect one more brain-related disorder via breath, in this case CP.
KW - breath
KW - cerebral palsy
KW - mid-infrared spectroscopy
KW - noninvasive medical diagnostics
KW - propionic acid esters
UR - http://www.scopus.com/inward/record.url?scp=85089453964&partnerID=8YFLogxK
U2 - 10.1002/jbio.202000125
DO - 10.1002/jbio.202000125
M3 - Article
C2 - 32526081
AN - SCOPUS:85089453964
SN - 1864-063X
VL - 13
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 11
M1 - e202000125
ER -