Bovine colostrum ameliorates diarrhea in infection with diarrheagenic Escherichia coli, Shiga toxin-producing E. coli, and E. coli expressing intimin and hemolysin

Hans Iko Huppertz, Stefan Rutkowski, Dirk H. Busch, Reinhard Eisebit, Reinhard Lissner, Helge Karch

Research output: Contribution to journalArticlepeer-review

64 Scopus citations

Abstract

Background: Diarrheagenic Escherichia coli may cause serious extraintestinal complications, but there is no specific treatment. Methods: Patients with diarrhea caused by diarrheagenic E. coli, specifically Shiga toxin-producing E. coli and E. coli-expressing intimin and enterohemorrhagic E. coli-hemolysin were treated by administration of pooled bovine colostrum, rich in antibodies to Shiga toxin and enterohemorrhagic E. coli-hemolysin, in a placebo-controlled, double-blind study. Symptom resolution and fecal excretion of infecting strains were assessed. Results: No side effects were attributable to colostrum. Stool frequencies in the group treated with bovine colostrum were significantly reduced compared with those in the placebo group. No effect of therapy on the carriage of the pathogens or on complications of the infection could be demonstrated. Conclusions: Bovine colostrum is well tolerated and diminishes frequency of loose stools in children with E. coli-associated diarrhea. A prospective study should be conducted among a larger number of children with Shiga toxin-producing E. coli identified early in illness, to determine the effectiveness of colostrum therapy. (C) 1999 Lippincott Williams and Wilkins, Inc.

Original languageEnglish
Pages (from-to)452-456
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume29
Issue number4
DOIs
StatePublished - Oct 1999
Externally publishedYes

Keywords

  • Bovine colostrum
  • Diarrhea
  • Diarrheagenic Escherichia coli
  • Hemolytic uremic syndrome

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