Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Lin Chiang Sherlock Huang, Dao Le, I. Lun Hsiao, Susanne Fritsch-Decker, Christian Hald, Su Ching Huang, Jen Kun Chen, Jih Ru Hwu, Carsten Weiss, Min Hua Hsu, Guillaume Delaittre

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalPolymer Chemistry
Issue number1
StatePublished - 7 Jan 2021
Externally publishedYes


Dive into the research topics of 'Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly'. Together they form a unique fingerprint.

Cite this