Boron containing magnetic nanoparticles for neutron capture therapy - an innovative approach for specifically targeting tumors

Rainer Tietze, Harald Unterweger, Stephan Dürr, Stefan Lyer, Lea Canella, Petra Kudejova, Franz M. Wagner, Winfried Petry, Nicola Taccardi, Christoph Alexiou

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The selective delivery of 10B into the tumor tissue remains to be further improved for successful and reliable Boron Neutron Capture Therapy applications. Magnetic Drug Targeting using intraarterially administered superparamagnetic nanoparticles and external magnetic fields already exhibited convincing results in terms of highly efficient and selective drug deposition. Using the same technique for the targeted 10B delivery is a promising new approach. Here, systematic irradiation experiments of phantom cubes containing different concentrations of boron and nanoparticles as well as varying three-dimensional arrangements have been performed.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalApplied Radiation and Isotopes
Volume106
DOIs
StatePublished - 1 Dec 2015

Keywords

  • BNCT
  • Magnetic Drug Targeting
  • Nanomedicine

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