Bone-marrow grafting in acute leukemia, aplastic anemia, and paroxysmal nocturnal hemoglobinuria in adults: Results of the department of internal medicine III, university of munich

U. Jehn, H. Sauer, H. J. Kolb, M. Fink, G. Ledderose, G. Brehm, W. Wilmanns, R. Eckstein, M. Heim, W. Mempel, H. v. Lieven, E. Bunde, R. Rohloff, O. Balk, E. Hochhäuser

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3 Scopus citations

Abstract

Eleven adults have been transplanted for various reasons between July 1979 and July 1982: 2 with aplastic anemia (AA), 1 with paroxysmal nocturnal hemoglobinuria (PNH), 8 with acute leukemia (AL). Four patients suffered from acute lymphocytic leukemia (ALL) and four from acute non-lymphocytic leukemia (ANLL). Two of them were transplanted in relapse, 1 in a partial remission, and 5 in complete remission. All patients were in their late stage of disease. The PNH-patient had an identical twin, 8 patients had an HLA- and MLC compatible sib, 1 an unrelated donor, and 1 was transplanted from his father. Four patients are alive, 2 more than 3 years: 1 with AA and 1 with ALL who was transplanted in relapse. Six patients died of infectious complications (4 of interstitial pneumonia, 1 of a candidasepsis, 1 of acute toxoplasmosis). Patients living more than 3 weeks had a take. Acute graft-versus-host (GvH) disease did not present a major problem. All patients received methotrexate for GvH-prophylaxis, in three instances the marrow was additionally pre-incubated with anti-T-cell globulin.

Translated title of the contributionKnochenmarktransplantation im Erwachsenenalter bei akuter Leukämie, aplastischer Anämie und paroxysmaler nächtlicher Hämoglobinurie: Ergebnisse der Medizinischen Klinik III der LMU München
Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalKlinische Wochenschrift
Volume61
Issue number7
DOIs
StatePublished - Apr 1983
Externally publishedYes

Keywords

  • Acuteleukemia
  • Aplastic-anemia
  • Bone-marrow-transplantation
  • Paroxysmal-nocturnal-hemoglobinuria

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