Bone marrow fat quantification in the presence of trabecular bone: Initial comparison between water-fat imaging and single-voxel MRS

Dimitrios C. Karampinos, Gerd Melkus, Thomas Baum, Jan S. Bauer, Ernst J. Rummeny, Roland Krug

Research output: Contribution to journalArticlepeer-review

124 Scopus citations

Abstract

Purpose The purpose of the present study was to test the relative performance of chemical shift-based water-fat imaging in measuring bone marrow fat fraction in the presence of trabecular bone, having as reference standard the single-voxel magnetic resonance spectroscopy (MRS). Methods Six-echo gradient echo imaging and single-voxel MRS measurements were performed on the proximal femur of seven healthy volunteers. The bone marrow fat spectrum was characterized based on the magnitude of measurable fat peaks and an a priori knowledge of the chemical structure of triglycerides, in order to accurately extract the water peak from the overlapping broad fat peaks in MRS. The imaging-based fat fraction results were then compared to the MRS-based results both without and with taking into consideration the presence of short T2* water components in MRS. Results There was a significant underestimation of the fat fraction using the MRS model not accounting for short T2* species with respect to the imaging-based fat fraction. A good equivalency was observed between the fat fraction using the MRS model accounting for short T2* species and the imaging-based fat fraction (R2 = 0.87). Conclusion The consideration of the short T2* water species effect on bone marrow fat quantification is essential when comparing MRS-based and imaging-based fat fraction results.

Original languageEnglish
Pages (from-to)1158-1165
Number of pages8
JournalMagnetic Resonance in Medicine
Volume71
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

Keywords

  • fat quantification
  • magnetic resonance imaging (MRI)
  • magnetic resonance spectroscopy (MRS)
  • red bone marrow
  • short T 2
  • species
  • water-fat separation

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