Bone marrow cells as precursors of the tumor stroma

Daniel L. Worthley; Yiling Si; Michael Quante; Michael Churchill; Siddhartha Mukherjee; Timothy C. Wang

doi:10.1016/j.yexcr.2013.03.006

Bone marrow cells as precursors of the tumor stroma

Daniel L. Worthley, Yiling Si, Michael Quante, Michael Churchill, Siddhartha Mukherjee, Timothy C. Wang

Department of Internal Medicine II - Gastroenterology

Columbia University

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy.

Original language	English
Pages (from-to)	1650-1656
Number of pages	7
Journal	Experimental Cell Research
Volume	319
Issue number	11
DOIs	https://doi.org/10.1016/j.yexcr.2013.03.006
State	Published - 1 Jul 2013

Keywords

Cancer
Carcinogenesis
Fibroblasts
Mesenchyme
Tumor microenvironment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.yexcr.2013.03.006

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title = "Bone marrow cells as precursors of the tumor stroma",

abstract = "Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy.",

keywords = "Cancer, Carcinogenesis, Fibroblasts, Mesenchyme, Tumor microenvironment",

author = "Worthley, {Daniel L.} and Yiling Si and Michael Quante and Michael Churchill and Siddhartha Mukherjee and Wang, {Timothy C.}",

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T1 - Bone marrow cells as precursors of the tumor stroma

AU - Worthley, Daniel L.

AU - Si, Yiling

AU - Quante, Michael

AU - Churchill, Michael

AU - Mukherjee, Siddhartha

AU - Wang, Timothy C.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy.

AB - Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy.

KW - Cancer

KW - Carcinogenesis

KW - Fibroblasts

KW - Mesenchyme

KW - Tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84879605585&partnerID=8YFLogxK

U2 - 10.1016/j.yexcr.2013.03.006

DO - 10.1016/j.yexcr.2013.03.006

M3 - Review article

C2 - 23499739

AN - SCOPUS:84879605585

SN - 0014-4827

VL - 319

SP - 1650

EP - 1656

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 11

ER -

Bone marrow cells as precursors of the tumor stroma

Abstract

Keywords

UN SDGs

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