Bone marrow cells as precursors of the tumor stroma

Daniel L. Worthley, Yiling Si, Michael Quante, Michael Churchill, Siddhartha Mukherjee, Timothy C. Wang

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy.

Original languageEnglish
Pages (from-to)1650-1656
Number of pages7
JournalExperimental Cell Research
Volume319
Issue number11
DOIs
StatePublished - 1 Jul 2013
Externally publishedYes

Keywords

  • Cancer
  • Carcinogenesis
  • Fibroblasts
  • Mesenchyme
  • Tumor microenvironment

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