BMD measurements of the spine derived from sagittal reformations of contrast-enhanced MDCT without dedicated software

Thomas Baum, Dirk Müller, Martin Dobritz, Ernst J. Rummeny, Thomas M. Link, Jan S. Bauer

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Purpose: To assess QCT equivalent BMD of the lumbar spine in sagittal reformations of routine abdominal contrast-enhanced MDCT with simple PACS measurement tools and to apply this method to MDCT datasets for differentiating patients with and without osteoporotic vertebral fractures. Materials and methods: Eight postmenopausal women (65 ± 5years) underwent standard QCT to assess BMD of L1-L3. Afterwards routine abdominal contrast-enhanced MDCT images of these women were obtained and apparent BMD of L1-L3 was measured using the sagittal reformations. The MDCT-to-QCT conversion equation for BMD was calculated with linear regression analysis. The conversion equation was applied to vertebral BMD datasets (L1-L3) of 75 postmenopausal women (66 ± 4years). Seventeen of the 75 patients had osteoporotic vertebral fractures. Results: BMD values of contrast-enhanced MDCT were on average 56 mg/ml higher than those of standard QCT. A correlation coefficient of r = 0.94 (p < 0.05) was calculated for the BMD values of MDCT and standard QCT with the conversion equation BMD QCT = 0.69 × BMD MDCT - 11 mg/ml. Accordingly converted BMD values of patients with vertebral fractures were significantly lower than those of patients without vertebral fractures (69 mg/ml vs. 85 mg/ml; p < 0.05). Using ROC analysis to differentiate patients with and without vertebral fractures, AUC = 0.72 was obtained for converted BMD values (p < 0.05). Short- and long-term reproducibility errors for BMD measurements in the sagittal reformations amounted 2.09% and 7.70%, respectively. Conclusion: BMD measurements of the spine could be computed in sagittal reformations of routine abdominal contrast-enhanced MDCT with minimal technical and time effort. Using the conversion equation, the acquired BMD data could differentiate patients with and without osteoporotic vertebral fractures.

Original languageEnglish
Pages (from-to)e140-e145
JournalEuropean Journal of Radiology
Volume80
Issue number2
DOIs
StatePublished - Nov 2011
Externally publishedYes

Keywords

  • Bone mineral density
  • Multi-detector CT
  • Osteoporosis
  • Quantitative CT
  • Sagittal reformations
  • Vertebral fractures

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