Abstract
Mongrel dogs were orally treated with 20 mg/kg amtilymphocyte globulin (ALG) or NHG. A significant decrease of the peripheral lymphocyte count was observed not only during 6 hours after the application of ALG but also during longterm observation. This lymphocytopenia was found to be between 30% and 50%. The effect of ALG after oral administration is less than after i.v. application. All other blood cells remained essentially unaffected by ALG as well as by normal horse gammaglobulin (NHG). Whereas the efficacy of i.v. applied ALG is reduced by antibody formation, this cannot be expected to the same degree during oral administration, because the antibody formation is markedly reduced by the oral route of application.
| Translated title of the contribution | Changes in the blood picture after a single and many times repeated oral administration of antilymphocyte globulin in the dog |
|---|---|
| Original language | German |
| Pages (from-to) | 147-151 |
| Number of pages | 5 |
| Journal | Langenbecks Archiv für Chirurgie |
| Volume | sup 1975 |
| State | Published - 1975 |
| Externally published | Yes |