TY - CHAP
T1 - Blood Supply and Oxygenation Status of the Liver
T2 - From Physiology to Malignancy
AU - Vaupel, Peter
AU - Multhoff, Gabriele
N1 - Publisher Copyright:
© 2022, Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - To maintain a multitude of vital functions, blood flow to the normal liver and the hepatic oxygenation status has to be kept on a high level (1.0–1.2 mL/g/min and 30–40 mmHg, respectively). There is a longitudinal oxygen partial pressure (pO2) gradient within the liver sinusoids between periportal inflow and outflow into the central vein leading to a zonation of the O2 status, which is associated with a zoning of liver functions. Oxygenation of metastatic lesions of colorectal cancers in the liver is poor due to a dysfunctional vascularity and inadequate blood supply. Hepatocellular carcinomas (HCCs) are highly vascularised (arterialised), metabolically very active and present with a predominantly arterial blood supply. HCCs are generally believed to be very hypoxic. However, confirmation of severe hypoxia based on reliable, direct pO2 measurements in HCCs is still missing.
AB - To maintain a multitude of vital functions, blood flow to the normal liver and the hepatic oxygenation status has to be kept on a high level (1.0–1.2 mL/g/min and 30–40 mmHg, respectively). There is a longitudinal oxygen partial pressure (pO2) gradient within the liver sinusoids between periportal inflow and outflow into the central vein leading to a zonation of the O2 status, which is associated with a zoning of liver functions. Oxygenation of metastatic lesions of colorectal cancers in the liver is poor due to a dysfunctional vascularity and inadequate blood supply. Hepatocellular carcinomas (HCCs) are highly vascularised (arterialised), metabolically very active and present with a predominantly arterial blood supply. HCCs are generally believed to be very hypoxic. However, confirmation of severe hypoxia based on reliable, direct pO2 measurements in HCCs is still missing.
KW - Hepatic arterial buffer response
KW - Hepatic blood flow
KW - Hepatic pO distribution
KW - Hepatocellular carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85144586165&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-14190-4_43
DO - 10.1007/978-3-031-14190-4_43
M3 - Chapter
C2 - 36527647
AN - SCOPUS:85144586165
T3 - Advances in Experimental Medicine and Biology
SP - 263
EP - 267
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -
