Blood Supply and Oxygenation Status of the Liver: From Physiology to Malignancy

Peter Vaupel, Gabriele Multhoff

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


To maintain a multitude of vital functions, blood flow to the normal liver and the hepatic oxygenation status has to be kept on a high level (1.0–1.2 mL/g/min and 30–40 mmHg, respectively). There is a longitudinal oxygen partial pressure (pO2) gradient within the liver sinusoids between periportal inflow and outflow into the central vein leading to a zonation of the O2 status, which is associated with a zoning of liver functions. Oxygenation of metastatic lesions of colorectal cancers in the liver is poor due to a dysfunctional vascularity and inadequate blood supply. Hepatocellular carcinomas (HCCs) are highly vascularised (arterialised), metabolically very active and present with a predominantly arterial blood supply. HCCs are generally believed to be very hypoxic. However, confirmation of severe hypoxia based on reliable, direct pO2 measurements in HCCs is still missing.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages5
StatePublished - 2022
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Hepatic arterial buffer response
  • Hepatic blood flow
  • Hepatic pO distribution
  • Hepatocellular carcinoma


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